Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

OBJECTIVE: The ATP-binding cassette transporter A1 (ABCA1) is essential for normal insulin secretion from β-cells. The aim of this study was to elucidate the mechanisms underlying the impaired insulin secretion in islets lacking β-cell ABCA1. RESEARCH DESIGN AND METHODS: Calcium imaging, patch clamp...

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Detalles Bibliográficos
Autores principales: Kruit, Janine K., Wijesekara, Nadeeja, Fox, Jocelyn E. Manning, Dai, Xiao-Qing, Brunham, Liam R., Searle, Gavin J., Morgan, Garry P., Costin, Adam J., Tang, Renmei, Bhattacharjee, Alpana, Johnson, James D., Light, Peter E., Marsh, Brad J., MacDonald, Patrick E., Verchere, C. Bruce, Hayden, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219942/
https://www.ncbi.nlm.nih.gov/pubmed/21998401
http://dx.doi.org/10.2337/db11-0081

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