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Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells

OBJECTIVE: The posttranslational regulation of glucokinase (GK) differs in hepatocytes and pancreatic β-cells. We tested the hypothesis that GK mutants that cause maturity-onset diabetes of the young (GK-MODY) show compromised activity and posttranslational regulation in β-cells. RESEARCH DESIGN AND...

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Detalles Bibliográficos
Autores principales:	Cullen, Kirsty S., Matschinsky, Franz M., Agius, Loranne, Arden, Catherine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219952/ https://www.ncbi.nlm.nih.gov/pubmed/22028181 http://dx.doi.org/10.2337/db11-0423

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