A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

Candidate antibacterials are usually identified on the basis of their in vitro activity. However, the apparent inhibitory activity of new leads can be misleading because most culture media do not reproduce an environment relevant to infection in vivo. In this study, while screening for novel anti-tu...

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Detalles Bibliográficos
Autores principales: Pethe, Kevin, Sequeira, Patricia C., Agarwalla, Sanjay, Rhee, Kyu, Kuhen, Kelli, Phong, Wai Yee, Patel, Viral, Beer, David, Walker, John R., Duraiswamy, Jeyaraj, Jiricek, Jan, Keller, Thomas H., Chatterjee, Arnab, Tan, Mai Ping, Ujjini, Manjunatha, Rao, Srinivasa P.S., Camacho, Luis, Bifani, Pablo, Mak, Puiying A., Ma, Ida, Barnes, S. Whitney, Chen, Zhong, Plouffe, David, Thayalan, Pamela, Ng, Seow Hwee, Au, Melvin, Lee, Boon Heng, Tan, Bee Huat, Ravindran, Sindhu, Nanjundappa, Mahesh, Lin, Xiuhua, Goh, Anne, Lakshminarayana, Suresh B., Shoen, Carolyn, Cynamon, Michael, Kreiswirth, Barry, Dartois, Veronique, Peters, Eric C., Glynne, Richard, Brenner, Sydney, Dick, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220188/
https://www.ncbi.nlm.nih.gov/pubmed/20975714
http://dx.doi.org/10.1038/ncomms1060

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