Analgesic Mechanism of Electroacupuncture in an Arthritic Pain Model of Rats: A Neurotransmitter Study

PURPOSE: We investigated what kinds of neurotransmitters are related with electroacupuncture (EA) analgesia in an arthritic pain model of rats. MATERIALS AND METHODS: One hundred rats were assigned to six groups: control, EA, opioid, adrenergic, serotonin and dopamine group. A standardized model of...

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Autores principales: Yoo, Young-Chul, Oh, Jin Hwan, Kwon, Tae Dong, Lee, Yeong Kyu, Bai, Sun Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220264/
https://www.ncbi.nlm.nih.gov/pubmed/22028168
http://dx.doi.org/10.3349/ymj.2011.52.6.1016
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author Yoo, Young-Chul
Oh, Jin Hwan
Kwon, Tae Dong
Lee, Yeong Kyu
Bai, Sun Joon
author_facet Yoo, Young-Chul
Oh, Jin Hwan
Kwon, Tae Dong
Lee, Yeong Kyu
Bai, Sun Joon
author_sort Yoo, Young-Chul
collection PubMed
description PURPOSE: We investigated what kinds of neurotransmitters are related with electroacupuncture (EA) analgesia in an arthritic pain model of rats. MATERIALS AND METHODS: One hundred rats were assigned to six groups: control, EA, opioid, adrenergic, serotonin and dopamine group. A standardized model of inflammatory arthritis was produced by injecting 2% carrageenan into the knee joint cavity. EA was applied to an acupoint for 30 min in all groups except fo the control group. In the opioid, adrenergic, serotonin and dopamine groups, each receptor antagonist was injected intraperitoneally to their respective group before initiating EA. RESULTS: In the opioid receptor antagonist group, adrenergic receptor antagonist group, serotonin receptor antagonist group, dopamine receptor antagonist group and the control group weight-bearing force decreased significantly from 30 min to 180 min after EA in comparison with the EA group. CONCLUSION: The analgesic effects of EA are related to opioid, adrenergic, serotonin and dopamine receptors in an arthritic pain model of rats.
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spelling pubmed-32202642011-11-21 Analgesic Mechanism of Electroacupuncture in an Arthritic Pain Model of Rats: A Neurotransmitter Study Yoo, Young-Chul Oh, Jin Hwan Kwon, Tae Dong Lee, Yeong Kyu Bai, Sun Joon Yonsei Med J Original Article PURPOSE: We investigated what kinds of neurotransmitters are related with electroacupuncture (EA) analgesia in an arthritic pain model of rats. MATERIALS AND METHODS: One hundred rats were assigned to six groups: control, EA, opioid, adrenergic, serotonin and dopamine group. A standardized model of inflammatory arthritis was produced by injecting 2% carrageenan into the knee joint cavity. EA was applied to an acupoint for 30 min in all groups except fo the control group. In the opioid, adrenergic, serotonin and dopamine groups, each receptor antagonist was injected intraperitoneally to their respective group before initiating EA. RESULTS: In the opioid receptor antagonist group, adrenergic receptor antagonist group, serotonin receptor antagonist group, dopamine receptor antagonist group and the control group weight-bearing force decreased significantly from 30 min to 180 min after EA in comparison with the EA group. CONCLUSION: The analgesic effects of EA are related to opioid, adrenergic, serotonin and dopamine receptors in an arthritic pain model of rats. Yonsei University College of Medicine 2011-11-01 2011-10-20 /pmc/articles/PMC3220264/ /pubmed/22028168 http://dx.doi.org/10.3349/ymj.2011.52.6.1016 Text en © Copyright: Yonsei University College of Medicine 2011 http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yoo, Young-Chul
Oh, Jin Hwan
Kwon, Tae Dong
Lee, Yeong Kyu
Bai, Sun Joon
Analgesic Mechanism of Electroacupuncture in an Arthritic Pain Model of Rats: A Neurotransmitter Study
title Analgesic Mechanism of Electroacupuncture in an Arthritic Pain Model of Rats: A Neurotransmitter Study
title_full Analgesic Mechanism of Electroacupuncture in an Arthritic Pain Model of Rats: A Neurotransmitter Study
title_fullStr Analgesic Mechanism of Electroacupuncture in an Arthritic Pain Model of Rats: A Neurotransmitter Study
title_full_unstemmed Analgesic Mechanism of Electroacupuncture in an Arthritic Pain Model of Rats: A Neurotransmitter Study
title_short Analgesic Mechanism of Electroacupuncture in an Arthritic Pain Model of Rats: A Neurotransmitter Study
title_sort analgesic mechanism of electroacupuncture in an arthritic pain model of rats: a neurotransmitter study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220264/
https://www.ncbi.nlm.nih.gov/pubmed/22028168
http://dx.doi.org/10.3349/ymj.2011.52.6.1016
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