The Deubiquitinase CYLD Targets Smad7 Protein to Regulate Transforming Growth Factor β (TGF-β) Signaling and the Development of Regulatory T Cells

CYLD is a lysine 63-deubiquitinating enzyme that inhibits NF-κB and JNK signaling. Here, we show that CYLD knock-out mice have markedly increased numbers of regulatory T cells (Tregs) in peripheral lymphoid organs but not in the thymus. In vitro stimulation of CYLD-deficient naive T cells with anti-...

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Detalles Bibliográficos
Autores principales: Zhao, Yongge, Thornton, Angela M., Kinney, Matthew C., Ma, Chi A., Spinner, Jacob J., Fuss, Ivan J., Shevach, Ethan M., Jain, Ashish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220473/
https://www.ncbi.nlm.nih.gov/pubmed/21931165
http://dx.doi.org/10.1074/jbc.M111.292961

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