Trypanosoma brucei Metacaspase 4 Is a Pseudopeptidase and a Virulence Factor

Metacaspases are caspase family cysteine peptidases found in plants, fungi, and protozoa but not mammals. Trypanosoma brucei is unusual in having five metacaspases (MCA1–MCA5), of which MCA1 and MCA4 have active site substitutions, making them possible non-enzymatic homologues. Here we demonstrate t...

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Detalles Bibliográficos
Autores principales: Proto, William R., Castanys-Munoz, Esther, Black, Alana, Tetley, Laurence, Moss, Catherine X., Juliano, Luiz, Coombs, Graham H., Mottram, Jeremy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220528/
https://www.ncbi.nlm.nih.gov/pubmed/21949125
http://dx.doi.org/10.1074/jbc.M111.292334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220528/
https://www.ncbi.nlm.nih.gov/pubmed/21949125
http://dx.doi.org/10.1074/jbc.M111.292334

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