A Single Bivalent Efficiently Inhibits Cyclin B1 Degradation and Polar Body Extrusion in Mouse Oocytes Indicating Robust SAC during Female Meiosis I

The Spindle Assembly Checkpoint (SAC) inhibits anaphase until microtubule-to-kinetochore attachments are formed, thus securing correct chromosome separation and preventing aneuploidy. Whereas in mitosis even a single unattached chromosome keeps the SAC active, the high incidence of aneuploidy relate...

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Detalles Bibliográficos
Autores principales: Hoffmann, Steffen, Maro, Bernard, Kubiak, Jacek Z., Polanski, Zbigniew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220673/
https://www.ncbi.nlm.nih.gov/pubmed/22125605
http://dx.doi.org/10.1371/journal.pone.0027143

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