A Chemical Genomic Analysis of Decoquinate, a Plasmodium falciparum Cytochrome b Inhibitor

[Image: see text] Decoquinate has single-digit nanomolar activity against in vitro blood stage Plasmodium falciparum parasites, the causative agent of human malaria. In vitro evolution of decoquinate-resistant parasites and subsequent comparative genomic analysis to the drug-sensitive parental strai...

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Detalles Bibliográficos
Autores principales: Nam, Tae-gyu, McNamara, Case W., Bopp, Selina, Dharia, Neekesh V., Meister, Stephan, Bonamy, Ghislain M. C., Plouffe, David M., Kato, Nobutaka, McCormack, Susan, Bursulaya, Badry, Ke, Hangjun, Vaidya, Akhil B., Schultz, Peter G., Winzeler, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220786/
https://www.ncbi.nlm.nih.gov/pubmed/21866942
http://dx.doi.org/10.1021/cb200105d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220786/
https://www.ncbi.nlm.nih.gov/pubmed/21866942
http://dx.doi.org/10.1021/cb200105d

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