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Pharmacokinetics of orally administered uracil in healthy volunteers and in DPD-deficient patients, a possible tool for screening of DPD deficiency

PURPOSE: Dihydropyrimidine dehydrogenase (DPD) deficiency can lead to severe toxicity in patients treated with standard doses of 5-fluorouracil (5-FU). Oral uracil administration and subsequent measurement of uracil and dihydrouracil (DHU) plasma concentrations might detect patients with DPD deficie...

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Detalles Bibliográficos
Autores principales:	van Staveren, Maurice C., Theeuwes-Oonk, Barbara, Guchelaar, Henk Jan, van Kuilenburg, André B. P., Maring, Jan Gerard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2011
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220818/ https://www.ncbi.nlm.nih.gov/pubmed/21590448 http://dx.doi.org/10.1007/s00280-011-1661-5

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