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Determinants of Body Fat in Infants of Women With Gestational Diabetes Mellitus Differ With Fetal Sex

OBJECTIVE: Neonatal adiposity is a well-recognized complication of gestational diabetes mellitus (GDM). This study aimed to identify factors influencing adiposity in male and female infants of women treated for GDM. RESEARCH DESIGN AND METHODS: This was a prospective study of 84 women with GDM. Dail...

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Autores principales: Lingwood, Barbara E., Henry, Alexandra M., d’Emden, Michael C., Fullerton, Amanda-Mei, Mortimer, Robin H., Colditz, Paul B., Lê Cao, Kim-Anh, Callaway, Leonie K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220854/
https://www.ncbi.nlm.nih.gov/pubmed/21994428
http://dx.doi.org/10.2337/dc11-0728
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author Lingwood, Barbara E.
Henry, Alexandra M.
d’Emden, Michael C.
Fullerton, Amanda-Mei
Mortimer, Robin H.
Colditz, Paul B.
Lê Cao, Kim-Anh
Callaway, Leonie K.
author_facet Lingwood, Barbara E.
Henry, Alexandra M.
d’Emden, Michael C.
Fullerton, Amanda-Mei
Mortimer, Robin H.
Colditz, Paul B.
Lê Cao, Kim-Anh
Callaway, Leonie K.
author_sort Lingwood, Barbara E.
collection PubMed
description OBJECTIVE: Neonatal adiposity is a well-recognized complication of gestational diabetes mellitus (GDM). This study aimed to identify factors influencing adiposity in male and female infants of women treated for GDM. RESEARCH DESIGN AND METHODS: This was a prospective study of 84 women with GDM. Daily blood glucose levels (BGLs) were retrieved from glucose meters, and overall mean fasting and mean 2-h postprandial BGLs were calculated for each woman. Infant body composition was measured at birth, and regression analysis was used to identify significant predictors of infant body fat separately in male and female infants. RESULTS: Maternal fasting BGL was the major predictor of adiposity in male infants but had little relationship to adiposity in female infants. In male infants, percent fat was increased by 0.44% for each 0.1 mmol/L increase in mean maternal fasting BGL. Maternal BMI was the primary predictor in female infants but had little effect in males. In female infants, percent fat was increased by 0.11% for each 1 kg/m(2) increase in maternal prepregnancy BMI. CONCLUSIONS: Fetal sex may influence the impact that treatment strategies for GDM have on infant adiposity.
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spelling pubmed-32208542012-12-01 Determinants of Body Fat in Infants of Women With Gestational Diabetes Mellitus Differ With Fetal Sex Lingwood, Barbara E. Henry, Alexandra M. d’Emden, Michael C. Fullerton, Amanda-Mei Mortimer, Robin H. Colditz, Paul B. Lê Cao, Kim-Anh Callaway, Leonie K. Diabetes Care Original Research OBJECTIVE: Neonatal adiposity is a well-recognized complication of gestational diabetes mellitus (GDM). This study aimed to identify factors influencing adiposity in male and female infants of women treated for GDM. RESEARCH DESIGN AND METHODS: This was a prospective study of 84 women with GDM. Daily blood glucose levels (BGLs) were retrieved from glucose meters, and overall mean fasting and mean 2-h postprandial BGLs were calculated for each woman. Infant body composition was measured at birth, and regression analysis was used to identify significant predictors of infant body fat separately in male and female infants. RESULTS: Maternal fasting BGL was the major predictor of adiposity in male infants but had little relationship to adiposity in female infants. In male infants, percent fat was increased by 0.44% for each 0.1 mmol/L increase in mean maternal fasting BGL. Maternal BMI was the primary predictor in female infants but had little effect in males. In female infants, percent fat was increased by 0.11% for each 1 kg/m(2) increase in maternal prepregnancy BMI. CONCLUSIONS: Fetal sex may influence the impact that treatment strategies for GDM have on infant adiposity. American Diabetes Association 2011-12 2011-11-14 /pmc/articles/PMC3220854/ /pubmed/21994428 http://dx.doi.org/10.2337/dc11-0728 Text en © 2011 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Lingwood, Barbara E.
Henry, Alexandra M.
d’Emden, Michael C.
Fullerton, Amanda-Mei
Mortimer, Robin H.
Colditz, Paul B.
Lê Cao, Kim-Anh
Callaway, Leonie K.
Determinants of Body Fat in Infants of Women With Gestational Diabetes Mellitus Differ With Fetal Sex
title Determinants of Body Fat in Infants of Women With Gestational Diabetes Mellitus Differ With Fetal Sex
title_full Determinants of Body Fat in Infants of Women With Gestational Diabetes Mellitus Differ With Fetal Sex
title_fullStr Determinants of Body Fat in Infants of Women With Gestational Diabetes Mellitus Differ With Fetal Sex
title_full_unstemmed Determinants of Body Fat in Infants of Women With Gestational Diabetes Mellitus Differ With Fetal Sex
title_short Determinants of Body Fat in Infants of Women With Gestational Diabetes Mellitus Differ With Fetal Sex
title_sort determinants of body fat in infants of women with gestational diabetes mellitus differ with fetal sex
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220854/
https://www.ncbi.nlm.nih.gov/pubmed/21994428
http://dx.doi.org/10.2337/dc11-0728
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