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The Role of the Sweet Taste Receptor in Enteroendocrine Cells and Pancreatic β-Cells

The sweet taste receptor is expressed in taste cells located in taste buds of the tongue. This receptor senses sweet substances in the oral cavity, activates taste cells, and transmits the taste signals to adjacent neurons. The sweet taste receptor is a heterodimer of two G protein-coupled receptors...

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Detalles Bibliográficos
Autores principales: Kojima, Itaru, Nakagawa, Yuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221019/
https://www.ncbi.nlm.nih.gov/pubmed/22111035
http://dx.doi.org/10.4093/dmj.2011.35.5.451
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author Kojima, Itaru
Nakagawa, Yuko
author_facet Kojima, Itaru
Nakagawa, Yuko
author_sort Kojima, Itaru
collection PubMed
description The sweet taste receptor is expressed in taste cells located in taste buds of the tongue. This receptor senses sweet substances in the oral cavity, activates taste cells, and transmits the taste signals to adjacent neurons. The sweet taste receptor is a heterodimer of two G protein-coupled receptors, T1R2 and T1R3. Recent studies have shown that this receptor is also expressed in the extragustatory system, including the gastrointestinal tract, pancreatic β-cells, and glucose-responsive neurons in the brain. In the intestine, the sweet taste receptor regulates secretion of incretin hormones and glucose uptake from the lumen. In β-cells, activation of the sweet taste receptor leads to stimulation of insulin secretion. Collectively, the sweet taste receptor plays an important role in recognition and metabolism of energy sources in the body.
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spelling pubmed-32210192011-11-22 The Role of the Sweet Taste Receptor in Enteroendocrine Cells and Pancreatic β-Cells Kojima, Itaru Nakagawa, Yuko Diabetes Metab J Review The sweet taste receptor is expressed in taste cells located in taste buds of the tongue. This receptor senses sweet substances in the oral cavity, activates taste cells, and transmits the taste signals to adjacent neurons. The sweet taste receptor is a heterodimer of two G protein-coupled receptors, T1R2 and T1R3. Recent studies have shown that this receptor is also expressed in the extragustatory system, including the gastrointestinal tract, pancreatic β-cells, and glucose-responsive neurons in the brain. In the intestine, the sweet taste receptor regulates secretion of incretin hormones and glucose uptake from the lumen. In β-cells, activation of the sweet taste receptor leads to stimulation of insulin secretion. Collectively, the sweet taste receptor plays an important role in recognition and metabolism of energy sources in the body. Korean Diabetes Association 2011-10 2011-10-31 /pmc/articles/PMC3221019/ /pubmed/22111035 http://dx.doi.org/10.4093/dmj.2011.35.5.451 Text en Copyright © 2011 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Kojima, Itaru
Nakagawa, Yuko
The Role of the Sweet Taste Receptor in Enteroendocrine Cells and Pancreatic β-Cells
title The Role of the Sweet Taste Receptor in Enteroendocrine Cells and Pancreatic β-Cells
title_full The Role of the Sweet Taste Receptor in Enteroendocrine Cells and Pancreatic β-Cells
title_fullStr The Role of the Sweet Taste Receptor in Enteroendocrine Cells and Pancreatic β-Cells
title_full_unstemmed The Role of the Sweet Taste Receptor in Enteroendocrine Cells and Pancreatic β-Cells
title_short The Role of the Sweet Taste Receptor in Enteroendocrine Cells and Pancreatic β-Cells
title_sort role of the sweet taste receptor in enteroendocrine cells and pancreatic β-cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221019/
https://www.ncbi.nlm.nih.gov/pubmed/22111035
http://dx.doi.org/10.4093/dmj.2011.35.5.451
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