Analgesic effect of Lepidium sativum Linn. (Chandrashura) in experimental animals

Lepidium sativum Linn, which is known as “Aselio” locally, is frequently used by the villagers for the treatment of Sandhivata (osteoarthritis), with good therapeutic relief. Here, we have to observe the analgesic activity of the seed of Lepidium sativum Linn in albino rats and Swiss albino mice with different parameters. The analgesic study was performed with acetic acid-induced writhing response in mice, formaldehyde-induced paw licking response in rats and tail flick response in mice. Experiments were carried out in two groups – therapeutic dose group and double dose group – with comparison with the control group. In the acetic acid-induced writhing syndrome, latency of onset was highly significantly increased in the therapeutic dose group and significant increase was found in the double dose group. In the formaldehyde-induced paw licking response, the test drug produced significant inhibition of neurogenic pain in the double dose group and significant inhibition of inflammatory pain in the therapeutic dose group. In the tail flick response, the test drug produced a mild to moderate effect in the therapeutic dose group and also in the double dose group.