ORAL ITRACONAZOLE FOR THE TREATMENT OF SEVERE SEBORRHOEIC DERMATITIS

BACKGROUND: Seborrheic dermatitis (SD) is an inflammatory skin disorder in which colonies of Malassezia furfur have been found in affected areas. AIM: The aim of this study was to evaluate the efficacy of itraconazole in the treatment of severe SD. MATERIALS AND METHODS: Itraconazole was given to 30...

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Autores principales: Das, Jayasri, Majumdar, Monalisa, Chakraborty, Urmita, Majumdar, Vivek, Mazumdar, Gautam, Nath, Jayasree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Therapeutic Round
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221212/
https://www.ncbi.nlm.nih.gov/pubmed/22121267
http://dx.doi.org/10.4103/0019-5154.87137
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author Das, Jayasri
Majumdar, Monalisa
Chakraborty, Urmita
Majumdar, Vivek
Mazumdar, Gautam
Nath, Jayasree
author_facet Das, Jayasri
Majumdar, Monalisa
Chakraborty, Urmita
Majumdar, Vivek
Mazumdar, Gautam
Nath, Jayasree
author_sort Das, Jayasri
collection PubMed
description BACKGROUND: Seborrheic dermatitis (SD) is an inflammatory skin disorder in which colonies of Malassezia furfur have been found in affected areas. AIM: The aim of this study was to evaluate the efficacy of itraconazole in the treatment of severe SD. MATERIALS AND METHODS: Itraconazole was given to 30 patients of SD in a dose of 100 mg twice daily for 1 week followed by 200 mg/day for first 2 days of the following 2 months. The response was noted on day 15, 30, 60, and 90. The clinical response was graded as markedly effective, effective, or ineffective. RESULTS: Clinical improvement (evaluated as markedly effective or effective) was observed in 83.3% cases. CONCLUSION: The anti-inflammatory activity of oral itraconazole suggests that it should be the first-line therapy in severe SD.
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spelling pubmed-32212122011-11-25 ORAL ITRACONAZOLE FOR THE TREATMENT OF SEVERE SEBORRHOEIC DERMATITIS Das, Jayasri Majumdar, Monalisa Chakraborty, Urmita Majumdar, Vivek Mazumdar, Gautam Nath, Jayasree Indian J Dermatol Therapeutic Round BACKGROUND: Seborrheic dermatitis (SD) is an inflammatory skin disorder in which colonies of Malassezia furfur have been found in affected areas. AIM: The aim of this study was to evaluate the efficacy of itraconazole in the treatment of severe SD. MATERIALS AND METHODS: Itraconazole was given to 30 patients of SD in a dose of 100 mg twice daily for 1 week followed by 200 mg/day for first 2 days of the following 2 months. The response was noted on day 15, 30, 60, and 90. The clinical response was graded as markedly effective, effective, or ineffective. RESULTS: Clinical improvement (evaluated as markedly effective or effective) was observed in 83.3% cases. CONCLUSION: The anti-inflammatory activity of oral itraconazole suggests that it should be the first-line therapy in severe SD. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3221212/ /pubmed/22121267 http://dx.doi.org/10.4103/0019-5154.87137 Text en Copyright: © Indian Journal of Dermatology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Therapeutic Round
Das, Jayasri
Majumdar, Monalisa
Chakraborty, Urmita
Majumdar, Vivek
Mazumdar, Gautam
Nath, Jayasree
ORAL ITRACONAZOLE FOR THE TREATMENT OF SEVERE SEBORRHOEIC DERMATITIS
title ORAL ITRACONAZOLE FOR THE TREATMENT OF SEVERE SEBORRHOEIC DERMATITIS
title_full ORAL ITRACONAZOLE FOR THE TREATMENT OF SEVERE SEBORRHOEIC DERMATITIS
title_fullStr ORAL ITRACONAZOLE FOR THE TREATMENT OF SEVERE SEBORRHOEIC DERMATITIS
title_full_unstemmed ORAL ITRACONAZOLE FOR THE TREATMENT OF SEVERE SEBORRHOEIC DERMATITIS
title_short ORAL ITRACONAZOLE FOR THE TREATMENT OF SEVERE SEBORRHOEIC DERMATITIS
title_sort oral itraconazole for the treatment of severe seborrhoeic dermatitis
topic Therapeutic Round
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221212/
https://www.ncbi.nlm.nih.gov/pubmed/22121267
http://dx.doi.org/10.4103/0019-5154.87137
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