Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by the pituitary gland and multiple cell types, including macrophages (Mø), dendritic cells (DC) and T-cells. Upon releases MIF modulates the expression of several inflammatory molecules, such as TNF-α, nitric oxide and...

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Detalles Bibliográficos
Autores principales: de Dios Rosado, Juan, Rodriguez-Sosa, Miriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221362/
https://www.ncbi.nlm.nih.gov/pubmed/22110378
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author de Dios Rosado, Juan
Rodriguez-Sosa, Miriam
author_facet de Dios Rosado, Juan
Rodriguez-Sosa, Miriam
author_sort de Dios Rosado, Juan
collection PubMed
description Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by the pituitary gland and multiple cell types, including macrophages (Mø), dendritic cells (DC) and T-cells. Upon releases MIF modulates the expression of several inflammatory molecules, such as TNF-α, nitric oxide and cyclooxygenase 2 (COX-2). These important MIF characteristics have prompted investigators to study its role in parasite infections. Several reports have demonstrated that MIF plays either a protective or deleterious role in the immune response to different pathogens. Here, we review the role of MIF in the host defense response to some important protozoan infections.
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spelling pubmed-32213622011-11-21 Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections de Dios Rosado, Juan Rodriguez-Sosa, Miriam Int J Biol Sci Review Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by the pituitary gland and multiple cell types, including macrophages (Mø), dendritic cells (DC) and T-cells. Upon releases MIF modulates the expression of several inflammatory molecules, such as TNF-α, nitric oxide and cyclooxygenase 2 (COX-2). These important MIF characteristics have prompted investigators to study its role in parasite infections. Several reports have demonstrated that MIF plays either a protective or deleterious role in the immune response to different pathogens. Here, we review the role of MIF in the host defense response to some important protozoan infections. Ivyspring International Publisher 2011-10-25 /pmc/articles/PMC3221362/ /pubmed/22110378 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Review
de Dios Rosado, Juan
Rodriguez-Sosa, Miriam
Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections
title Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections
title_full Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections
title_fullStr Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections
title_full_unstemmed Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections
title_short Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections
title_sort macrophage migration inhibitory factor (mif): a key player in protozoan infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221362/
https://www.ncbi.nlm.nih.gov/pubmed/22110378
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