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Identification of Major Degradation Products of Ketoconazole

Analytical methods were developed for the identification of major degradation products of Ketoconazole, an antifungal agent. The stressed degradation of Ketoconazole drug substance was performed under acid, base, thermal, photo and oxidative stress conditions. The major degradation was observed unde...

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Detalles Bibliográficos
Autores principales: Mhaske, Rajendra A., Sahasrabudhe, Shirish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221500/
https://www.ncbi.nlm.nih.gov/pubmed/22145107
http://dx.doi.org/10.3797/scipharm.1107-18
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author Mhaske, Rajendra A.
Sahasrabudhe, Shirish
author_facet Mhaske, Rajendra A.
Sahasrabudhe, Shirish
author_sort Mhaske, Rajendra A.
collection PubMed
description Analytical methods were developed for the identification of major degradation products of Ketoconazole, an antifungal agent. The stressed degradation of Ketoconazole drug substance was performed under acid, base, thermal, photo and oxidative stress conditions. The major degradation was observed under acid, base and oxidative stress conditions. The degradation study was performed on Inertsil ODS-3V, length 100 X diameter 4.6 mm, particle size 3 μm column using gradient method. These degradants were identified by LC-MS technique.
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spelling pubmed-32215002011-12-05 Identification of Major Degradation Products of Ketoconazole Mhaske, Rajendra A. Sahasrabudhe, Shirish Sci Pharm Research Article Analytical methods were developed for the identification of major degradation products of Ketoconazole, an antifungal agent. The stressed degradation of Ketoconazole drug substance was performed under acid, base, thermal, photo and oxidative stress conditions. The major degradation was observed under acid, base and oxidative stress conditions. The degradation study was performed on Inertsil ODS-3V, length 100 X diameter 4.6 mm, particle size 3 μm column using gradient method. These degradants were identified by LC-MS technique. Österreichische Apotheker-Verlagsgesellschaft 2011 2011-10-13 /pmc/articles/PMC3221500/ /pubmed/22145107 http://dx.doi.org/10.3797/scipharm.1107-18 Text en © Mhaske and Sahasrabudhe; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mhaske, Rajendra A.
Sahasrabudhe, Shirish
Identification of Major Degradation Products of Ketoconazole
title Identification of Major Degradation Products of Ketoconazole
title_full Identification of Major Degradation Products of Ketoconazole
title_fullStr Identification of Major Degradation Products of Ketoconazole
title_full_unstemmed Identification of Major Degradation Products of Ketoconazole
title_short Identification of Major Degradation Products of Ketoconazole
title_sort identification of major degradation products of ketoconazole
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221500/
https://www.ncbi.nlm.nih.gov/pubmed/22145107
http://dx.doi.org/10.3797/scipharm.1107-18
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