Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A–C: Fibronectin Expression Regulators from Aspergillus novofumigatus

Three new quinazolinobenzodiazepine derivatives, novobenzomalvins A (1), B (2), and C (3), have been isolated as fibronectin expression regulators from Aspergillus novofumigatus CBS117520. The structures of 1 to 3 were established by spectroscopic and physicochemical analysis, and chemical investiga...

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Autores principales: Ishikawa, Kazuki, Hosoe, Tomoo, Itabashi, Takeshi, Sato, Fumiaki, Wachi, Hiroshi, Nagase, Hiromasa, Yaguchi, Takashi, Kawai, Ken-Ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221506/
https://www.ncbi.nlm.nih.gov/pubmed/22145116
http://dx.doi.org/10.3797/scipharm.1106-21
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author Ishikawa, Kazuki
Hosoe, Tomoo
Itabashi, Takeshi
Sato, Fumiaki
Wachi, Hiroshi
Nagase, Hiromasa
Yaguchi, Takashi
Kawai, Ken-Ichi
author_facet Ishikawa, Kazuki
Hosoe, Tomoo
Itabashi, Takeshi
Sato, Fumiaki
Wachi, Hiroshi
Nagase, Hiromasa
Yaguchi, Takashi
Kawai, Ken-Ichi
author_sort Ishikawa, Kazuki
collection PubMed
description Three new quinazolinobenzodiazepine derivatives, novobenzomalvins A (1), B (2), and C (3), have been isolated as fibronectin expression regulators from Aspergillus novofumigatus CBS117520. The structures of 1 to 3 were established by spectroscopic and physicochemical analysis, and chemical investigation including the total synthesis of 1. Treatment with novo-benzomalvins A (1), B (2), C (3), and N-methylnovobenzomalvin A (5) increased the expression of fibronectin in normal human neonatal dermal fibroblast cells.
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spelling pubmed-32215062011-12-05 Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A–C: Fibronectin Expression Regulators from Aspergillus novofumigatus Ishikawa, Kazuki Hosoe, Tomoo Itabashi, Takeshi Sato, Fumiaki Wachi, Hiroshi Nagase, Hiromasa Yaguchi, Takashi Kawai, Ken-Ichi Sci Pharm Research Article Three new quinazolinobenzodiazepine derivatives, novobenzomalvins A (1), B (2), and C (3), have been isolated as fibronectin expression regulators from Aspergillus novofumigatus CBS117520. The structures of 1 to 3 were established by spectroscopic and physicochemical analysis, and chemical investigation including the total synthesis of 1. Treatment with novo-benzomalvins A (1), B (2), C (3), and N-methylnovobenzomalvin A (5) increased the expression of fibronectin in normal human neonatal dermal fibroblast cells. Österreichische Apotheker-Verlagsgesellschaft 2011 2011-10-03 /pmc/articles/PMC3221506/ /pubmed/22145116 http://dx.doi.org/10.3797/scipharm.1106-21 Text en © Ishikawa et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ishikawa, Kazuki
Hosoe, Tomoo
Itabashi, Takeshi
Sato, Fumiaki
Wachi, Hiroshi
Nagase, Hiromasa
Yaguchi, Takashi
Kawai, Ken-Ichi
Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A–C: Fibronectin Expression Regulators from Aspergillus novofumigatus
title Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A–C: Fibronectin Expression Regulators from Aspergillus novofumigatus
title_full Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A–C: Fibronectin Expression Regulators from Aspergillus novofumigatus
title_fullStr Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A–C: Fibronectin Expression Regulators from Aspergillus novofumigatus
title_full_unstemmed Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A–C: Fibronectin Expression Regulators from Aspergillus novofumigatus
title_short Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A–C: Fibronectin Expression Regulators from Aspergillus novofumigatus
title_sort quinazolinobenzodiazepine derivatives, novobenzomalvins a–c: fibronectin expression regulators from aspergillus novofumigatus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221506/
https://www.ncbi.nlm.nih.gov/pubmed/22145116
http://dx.doi.org/10.3797/scipharm.1106-21
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