Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila

Spinocerebellar ataxia type 3 is one of the polyglutamine (polyQ) diseases, which are caused by a CAG-repeat expansion within the coding region of the associated genes. The CAG repeat specifies glutamine, and the expanded polyQ domain mutation confers dominant toxicity on the protein. Traditionally,...

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Detalles Bibliográficos
Autores principales: Shieh, Shin-Yi, Bonini, Nancy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221540/
https://www.ncbi.nlm.nih.gov/pubmed/21933837
http://dx.doi.org/10.1093/hmg/ddr420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221540/
https://www.ncbi.nlm.nih.gov/pubmed/21933837
http://dx.doi.org/10.1093/hmg/ddr420

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