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Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila
Spinocerebellar ataxia type 3 is one of the polyglutamine (polyQ) diseases, which are caused by a CAG-repeat expansion within the coding region of the associated genes. The CAG repeat specifies glutamine, and the expanded polyQ domain mutation confers dominant toxicity on the protein. Traditionally,...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221540/ https://www.ncbi.nlm.nih.gov/pubmed/21933837 http://dx.doi.org/10.1093/hmg/ddr420 |