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Evaluation of SLOG/TCI-III pediatric system on target control infusion of propofol

BACKGROUND: The target-controlled infusion-III (SLOG/TCI-III) system was derived from a model set up by the local pediatric population for target control infusion of propofol. METHODS: The current study aimed at evaluating the difference between target concentrations of propofol and performance, whi...

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Autores principales: Yang, Wan-hua, Gu, Hong-bin, Chen, Bing, Li, Juan, Fan, Qiu-wei, Yuan , Yong-fang, Wang, Xiangdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221635/
https://www.ncbi.nlm.nih.gov/pubmed/22044738
http://dx.doi.org/10.1186/1479-5876-9-187
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author Yang, Wan-hua
Gu, Hong-bin
Chen, Bing
Li, Juan
Fan, Qiu-wei
Yuan , Yong-fang
Wang, Xiangdong
author_facet Yang, Wan-hua
Gu, Hong-bin
Chen, Bing
Li, Juan
Fan, Qiu-wei
Yuan , Yong-fang
Wang, Xiangdong
author_sort Yang, Wan-hua
collection PubMed
description BACKGROUND: The target-controlled infusion-III (SLOG/TCI-III) system was derived from a model set up by the local pediatric population for target control infusion of propofol. METHODS: The current study aimed at evaluating the difference between target concentrations of propofol and performance, which was measured using the SLOG/TCI-III system in children. Thirty children fulfilling the I-II criteria according to American Society of Anesthesiology were enrolled in the study. The target plasma concentration of propofol was fed into the SLOG/TCI-III system and compared with the measured concentrations of propofol. Blood samples were collected and analyzed by high performance liquid chromatography with fluorescence detector. The performance error (PE) was determined for each measured blood propofol concentration. The performances of the TCI-III system were determined by the median performance error (MDPE), the median absolute performance error (MDAPE), and Wobble (the median absolute deviation of each PE from the MDPE), respectively. RESULTS: Concentration against target concentration showed good linear correlation: concentration = 1.3428 target concentration - 0.2633 (r = 0.8667). The MDPE and MDAPE of the pediatric system were 10 and 22%, respectively, and the median value for Wobble was 24%. MDPE and MDAPE were less than 15 and 30%, respectively. CONCLUSIONS: The performance of TCI-III system seems to be in the accepted limits for clinical practice in children.
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spelling pubmed-32216352011-11-22 Evaluation of SLOG/TCI-III pediatric system on target control infusion of propofol Yang, Wan-hua Gu, Hong-bin Chen, Bing Li, Juan Fan, Qiu-wei Yuan , Yong-fang Wang, Xiangdong J Transl Med Research BACKGROUND: The target-controlled infusion-III (SLOG/TCI-III) system was derived from a model set up by the local pediatric population for target control infusion of propofol. METHODS: The current study aimed at evaluating the difference between target concentrations of propofol and performance, which was measured using the SLOG/TCI-III system in children. Thirty children fulfilling the I-II criteria according to American Society of Anesthesiology were enrolled in the study. The target plasma concentration of propofol was fed into the SLOG/TCI-III system and compared with the measured concentrations of propofol. Blood samples were collected and analyzed by high performance liquid chromatography with fluorescence detector. The performance error (PE) was determined for each measured blood propofol concentration. The performances of the TCI-III system were determined by the median performance error (MDPE), the median absolute performance error (MDAPE), and Wobble (the median absolute deviation of each PE from the MDPE), respectively. RESULTS: Concentration against target concentration showed good linear correlation: concentration = 1.3428 target concentration - 0.2633 (r = 0.8667). The MDPE and MDAPE of the pediatric system were 10 and 22%, respectively, and the median value for Wobble was 24%. MDPE and MDAPE were less than 15 and 30%, respectively. CONCLUSIONS: The performance of TCI-III system seems to be in the accepted limits for clinical practice in children. BioMed Central 2011-11-01 /pmc/articles/PMC3221635/ /pubmed/22044738 http://dx.doi.org/10.1186/1479-5876-9-187 Text en Copyright ©2011 Yang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Yang, Wan-hua
Gu, Hong-bin
Chen, Bing
Li, Juan
Fan, Qiu-wei
Yuan , Yong-fang
Wang, Xiangdong
Evaluation of SLOG/TCI-III pediatric system on target control infusion of propofol
title Evaluation of SLOG/TCI-III pediatric system on target control infusion of propofol
title_full Evaluation of SLOG/TCI-III pediatric system on target control infusion of propofol
title_fullStr Evaluation of SLOG/TCI-III pediatric system on target control infusion of propofol
title_full_unstemmed Evaluation of SLOG/TCI-III pediatric system on target control infusion of propofol
title_short Evaluation of SLOG/TCI-III pediatric system on target control infusion of propofol
title_sort evaluation of slog/tci-iii pediatric system on target control infusion of propofol
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221635/
https://www.ncbi.nlm.nih.gov/pubmed/22044738
http://dx.doi.org/10.1186/1479-5876-9-187
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