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Evaluation of an AAV2-Based Rapamycin-Regulated Glial Cell Line-Derived Neurotrophic Factor (GDNF) Expression Vector System

Effective regulation of transgene product in anatomically circumscribed brain tissue is dependent on the pharmacokinetics of the regulating agent, the kinetics of transcriptional activation and degradation of the transgene product. We evaluated rapamycin-regulated AAV2-GDNF expression in the rat bra...

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Detalles Bibliográficos
Autores principales:	Hadaczek, Piotr, Beyer, Janine, Kells, Adrian, Narrow, Wade, Bowers, William, Federoff, Howard J., Forsayeth, John, Bankiewicz, Krystof S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221672/ https://www.ncbi.nlm.nih.gov/pubmed/22132130 http://dx.doi.org/10.1371/journal.pone.0027728

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