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Severely Impaired Learning and Altered Neuronal Morphology in Mice Lacking NMDA Receptors in Medium Spiny Neurons
The striatum is composed predominantly of medium spiny neurons (MSNs) that integrate excitatory, glutamatergic inputs from the cortex and thalamus, and modulatory dopaminergic inputs from the ventral midbrain to influence behavior. Glutamatergic activation of AMPA, NMDA, and metabotropic receptors o...
Autores principales: | Beutler, Lisa R., Eldred, Kiara C., Quintana, Albert, Keene, C. Dirk, Rose, Shannon E., Postupna, Nadia, Montine, Thomas J., Palmiter, Richard D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221701/ https://www.ncbi.nlm.nih.gov/pubmed/22132236 http://dx.doi.org/10.1371/journal.pone.0028168 |
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