tRNA structural and functional changes induced by oxidative stress

Oxidatively damaged biomolecules impair cellular functions and contribute to the pathology of a variety of diseases. RNA is also attacked by reactive oxygen species, and oxidized RNA is increasingly recognized as an important contributor to neurodegenerative complications in humans. Recently, eviden...

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Detalles Bibliográficos
Autores principales: Nawrot, Barbara, Sochacka, Elzbieta, Düchler, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Birkhäuser Verlag Basel 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221842/
https://www.ncbi.nlm.nih.gov/pubmed/21833586
http://dx.doi.org/10.1007/s00018-011-0773-8
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author Nawrot, Barbara
Sochacka, Elzbieta
Düchler, Markus
author_facet Nawrot, Barbara
Sochacka, Elzbieta
Düchler, Markus
author_sort Nawrot, Barbara
collection PubMed
description Oxidatively damaged biomolecules impair cellular functions and contribute to the pathology of a variety of diseases. RNA is also attacked by reactive oxygen species, and oxidized RNA is increasingly recognized as an important contributor to neurodegenerative complications in humans. Recently, evidence has accumulated supporting the notion that tRNA is involved in cellular responses to various stress conditions. This review focuses on the intriguing consequences of oxidative modification of tRNA at the structural and functional level.
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spelling pubmed-32218422011-12-27 tRNA structural and functional changes induced by oxidative stress Nawrot, Barbara Sochacka, Elzbieta Düchler, Markus Cell Mol Life Sci Review Oxidatively damaged biomolecules impair cellular functions and contribute to the pathology of a variety of diseases. RNA is also attacked by reactive oxygen species, and oxidized RNA is increasingly recognized as an important contributor to neurodegenerative complications in humans. Recently, evidence has accumulated supporting the notion that tRNA is involved in cellular responses to various stress conditions. This review focuses on the intriguing consequences of oxidative modification of tRNA at the structural and functional level. SP Birkhäuser Verlag Basel 2011-08-11 2011 /pmc/articles/PMC3221842/ /pubmed/21833586 http://dx.doi.org/10.1007/s00018-011-0773-8 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Review
Nawrot, Barbara
Sochacka, Elzbieta
Düchler, Markus
tRNA structural and functional changes induced by oxidative stress
title tRNA structural and functional changes induced by oxidative stress
title_full tRNA structural and functional changes induced by oxidative stress
title_fullStr tRNA structural and functional changes induced by oxidative stress
title_full_unstemmed tRNA structural and functional changes induced by oxidative stress
title_short tRNA structural and functional changes induced by oxidative stress
title_sort trna structural and functional changes induced by oxidative stress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221842/
https://www.ncbi.nlm.nih.gov/pubmed/21833586
http://dx.doi.org/10.1007/s00018-011-0773-8
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