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Glucocorticoids in the treatment of neonatal meconium aspiration syndrome
Meconium aspiration syndrome is a serious neonatal disease with complex pathophysiology. With respect to the contribution of meconium-induced lung edema, inflammation and vasoconstriction on the course of the disease, glucocorticoids are increasingly used in the treatment of MAS despite the fact tha...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221844/ https://www.ncbi.nlm.nih.gov/pubmed/21465122 http://dx.doi.org/10.1007/s00431-011-1453-2 |
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author | Mokra, Daniela Mokry, Juraj |
author_facet | Mokra, Daniela Mokry, Juraj |
author_sort | Mokra, Daniela |
collection | PubMed |
description | Meconium aspiration syndrome is a serious neonatal disease with complex pathophysiology. With respect to the contribution of meconium-induced lung edema, inflammation and vasoconstriction on the course of the disease, glucocorticoids are increasingly used in the treatment of MAS despite the fact that principal questions on the choice of GCs derivative, mode of delivery and dosing have not been answered yet. To bring a complex insight into the topic, this article reviews the pathomechanisms of MAS, mechanisms of action of GCs, as well as the advantages and disadvantages of GCs administration in experimental models and newborns with MAS. |
format | Online Article Text |
id | pubmed-3221844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-32218442011-12-27 Glucocorticoids in the treatment of neonatal meconium aspiration syndrome Mokra, Daniela Mokry, Juraj Eur J Pediatr Review Meconium aspiration syndrome is a serious neonatal disease with complex pathophysiology. With respect to the contribution of meconium-induced lung edema, inflammation and vasoconstriction on the course of the disease, glucocorticoids are increasingly used in the treatment of MAS despite the fact that principal questions on the choice of GCs derivative, mode of delivery and dosing have not been answered yet. To bring a complex insight into the topic, this article reviews the pathomechanisms of MAS, mechanisms of action of GCs, as well as the advantages and disadvantages of GCs administration in experimental models and newborns with MAS. Springer-Verlag 2011-04-06 2011 /pmc/articles/PMC3221844/ /pubmed/21465122 http://dx.doi.org/10.1007/s00431-011-1453-2 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Review Mokra, Daniela Mokry, Juraj Glucocorticoids in the treatment of neonatal meconium aspiration syndrome |
title | Glucocorticoids in the treatment of neonatal meconium aspiration syndrome |
title_full | Glucocorticoids in the treatment of neonatal meconium aspiration syndrome |
title_fullStr | Glucocorticoids in the treatment of neonatal meconium aspiration syndrome |
title_full_unstemmed | Glucocorticoids in the treatment of neonatal meconium aspiration syndrome |
title_short | Glucocorticoids in the treatment of neonatal meconium aspiration syndrome |
title_sort | glucocorticoids in the treatment of neonatal meconium aspiration syndrome |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221844/ https://www.ncbi.nlm.nih.gov/pubmed/21465122 http://dx.doi.org/10.1007/s00431-011-1453-2 |
work_keys_str_mv | AT mokradaniela glucocorticoidsinthetreatmentofneonatalmeconiumaspirationsyndrome AT mokryjuraj glucocorticoidsinthetreatmentofneonatalmeconiumaspirationsyndrome |