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Sizing the lung of mechanically ventilated patients

INTRODUCTION: This small observational study was motivated by our belief that scaling the tidal volume in mechanically ventilated patients to the size of the injured lung is safer and more 'physiologic' than scaling it to predicted body weight, i.e. its size before it was injured. We defin...

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Autores principales: Mattingley, Jennifer S, Holets, Steven R, Oeckler, Richard A, Stroetz, Randolph W, Buck, Curtis F, Hubmayr, Rolf D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221993/
https://www.ncbi.nlm.nih.gov/pubmed/21320330
http://dx.doi.org/10.1186/cc10034
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author Mattingley, Jennifer S
Holets, Steven R
Oeckler, Richard A
Stroetz, Randolph W
Buck, Curtis F
Hubmayr, Rolf D
author_facet Mattingley, Jennifer S
Holets, Steven R
Oeckler, Richard A
Stroetz, Randolph W
Buck, Curtis F
Hubmayr, Rolf D
author_sort Mattingley, Jennifer S
collection PubMed
description INTRODUCTION: This small observational study was motivated by our belief that scaling the tidal volume in mechanically ventilated patients to the size of the injured lung is safer and more 'physiologic' than scaling it to predicted body weight, i.e. its size before it was injured. We defined Total Lung Capacity (TLC) as the thoracic gas volume at an airway pressure of 40 cm H2O and tested if TLC could be inferred from the volume of gas that enters the lungs during a brief 'recruitment' maneuver. METHODS: Lung volume at relaxed end expiration (Vrel) as well as inspiratory capacity (IC), defined as the volume of gas that enters the lung during a 5 second inflation to 40 cm H2O, were measured in 14 patients with respiratory failure. TLC was defined as the sum of IC and Vrel. The dependence of IC and Vrel on body mass index (BMI), respiratory system elastance and plateau airway pressure was assessed. RESULTS: TLC was reduced to 59 ± 23% of that predicted. Vrel/TLC, which averaged 0.45 ± 0.11, was no different than the 0.47 ± 0.04 predicted during health in the supine posture. The greater than expected variability in observed Vrel/TLC was largely accounted for by BMI. Vrel and IC were correlated (r = 0.76). Taking BMI into account strengthened the correlation (r = 0.92). CONCLUSIONS: We conclude that body mass is a powerful determinant of lung volume and plateau airway pressure. Effective lung size can be easily estimated from a recruitment maneuver derived inspiratory capacity measurement and body mass index.
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spelling pubmed-32219932011-11-22 Sizing the lung of mechanically ventilated patients Mattingley, Jennifer S Holets, Steven R Oeckler, Richard A Stroetz, Randolph W Buck, Curtis F Hubmayr, Rolf D Crit Care Research INTRODUCTION: This small observational study was motivated by our belief that scaling the tidal volume in mechanically ventilated patients to the size of the injured lung is safer and more 'physiologic' than scaling it to predicted body weight, i.e. its size before it was injured. We defined Total Lung Capacity (TLC) as the thoracic gas volume at an airway pressure of 40 cm H2O and tested if TLC could be inferred from the volume of gas that enters the lungs during a brief 'recruitment' maneuver. METHODS: Lung volume at relaxed end expiration (Vrel) as well as inspiratory capacity (IC), defined as the volume of gas that enters the lung during a 5 second inflation to 40 cm H2O, were measured in 14 patients with respiratory failure. TLC was defined as the sum of IC and Vrel. The dependence of IC and Vrel on body mass index (BMI), respiratory system elastance and plateau airway pressure was assessed. RESULTS: TLC was reduced to 59 ± 23% of that predicted. Vrel/TLC, which averaged 0.45 ± 0.11, was no different than the 0.47 ± 0.04 predicted during health in the supine posture. The greater than expected variability in observed Vrel/TLC was largely accounted for by BMI. Vrel and IC were correlated (r = 0.76). Taking BMI into account strengthened the correlation (r = 0.92). CONCLUSIONS: We conclude that body mass is a powerful determinant of lung volume and plateau airway pressure. Effective lung size can be easily estimated from a recruitment maneuver derived inspiratory capacity measurement and body mass index. BioMed Central 2011 2011-02-14 /pmc/articles/PMC3221993/ /pubmed/21320330 http://dx.doi.org/10.1186/cc10034 Text en Copyright ©2011 Mattingley et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Mattingley, Jennifer S
Holets, Steven R
Oeckler, Richard A
Stroetz, Randolph W
Buck, Curtis F
Hubmayr, Rolf D
Sizing the lung of mechanically ventilated patients
title Sizing the lung of mechanically ventilated patients
title_full Sizing the lung of mechanically ventilated patients
title_fullStr Sizing the lung of mechanically ventilated patients
title_full_unstemmed Sizing the lung of mechanically ventilated patients
title_short Sizing the lung of mechanically ventilated patients
title_sort sizing the lung of mechanically ventilated patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221993/
https://www.ncbi.nlm.nih.gov/pubmed/21320330
http://dx.doi.org/10.1186/cc10034
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