PCR for the diagnosis of sepsis: hope or hype?

Molecular biology has not yet fully reached its ambitious goals in clinical bacteriology. Notwithstanding the tremendous technical challenges, the detection of nucleic acids directly from the blood of septic patients has not been shown cost-effective or even clinically relevant. Yet the potential fo...

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Detalles Bibliográficos
Autor principal: Schrenzel, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222021/
https://www.ncbi.nlm.nih.gov/pubmed/21345277
http://dx.doi.org/10.1186/cc9378
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author Schrenzel, Jacques
author_facet Schrenzel, Jacques
author_sort Schrenzel, Jacques
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description Molecular biology has not yet fully reached its ambitious goals in clinical bacteriology. Notwithstanding the tremendous technical challenges, the detection of nucleic acids directly from the blood of septic patients has not been shown cost-effective or even clinically relevant. Yet the potential for rapid molecular detection of circulating DNA (DNAemia) coupled to an educated antimicrobial drug adaptation has been repetitively advocated as a predicted breakthrough. Why do we still remain in such uncertainty?
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spelling pubmed-32220212012-01-26 PCR for the diagnosis of sepsis: hope or hype? Schrenzel, Jacques Crit Care Commentary Molecular biology has not yet fully reached its ambitious goals in clinical bacteriology. Notwithstanding the tremendous technical challenges, the detection of nucleic acids directly from the blood of septic patients has not been shown cost-effective or even clinically relevant. Yet the potential for rapid molecular detection of circulating DNA (DNAemia) coupled to an educated antimicrobial drug adaptation has been repetitively advocated as a predicted breakthrough. Why do we still remain in such uncertainty? BioMed Central 2011 2011-01-26 /pmc/articles/PMC3222021/ /pubmed/21345277 http://dx.doi.org/10.1186/cc9378 Text en Copyright ©2011 BioMed Central Ltd
spellingShingle Commentary
Schrenzel, Jacques
PCR for the diagnosis of sepsis: hope or hype?
title PCR for the diagnosis of sepsis: hope or hype?
title_full PCR for the diagnosis of sepsis: hope or hype?
title_fullStr PCR for the diagnosis of sepsis: hope or hype?
title_full_unstemmed PCR for the diagnosis of sepsis: hope or hype?
title_short PCR for the diagnosis of sepsis: hope or hype?
title_sort pcr for the diagnosis of sepsis: hope or hype?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222021/
https://www.ncbi.nlm.nih.gov/pubmed/21345277
http://dx.doi.org/10.1186/cc9378
work_keys_str_mv AT schrenzeljacques pcrforthediagnosisofsepsishopeorhype

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