A Gene Network Perspective on Axonal Regeneration

The regenerative capacity of injured neurons in the central nervous system is limited due to the absence of a robust neuron-intrinsic injury-induced gene response that supports axon regeneration. In peripheral neurons axotomy induces a large cohort of regeneration-associated genes (RAGs). The forced...

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Autores principales: van Kesteren, Ronald E., Mason, Matthew R. J., MacGillavry, Harold D., Smit, August B., Verhaagen, Joost
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222109/
https://www.ncbi.nlm.nih.gov/pubmed/22125511
http://dx.doi.org/10.3389/fnmol.2011.00046
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author van Kesteren, Ronald E.
Mason, Matthew R. J.
MacGillavry, Harold D.
Smit, August B.
Verhaagen, Joost
author_facet van Kesteren, Ronald E.
Mason, Matthew R. J.
MacGillavry, Harold D.
Smit, August B.
Verhaagen, Joost
author_sort van Kesteren, Ronald E.
collection PubMed
description The regenerative capacity of injured neurons in the central nervous system is limited due to the absence of a robust neuron-intrinsic injury-induced gene response that supports axon regeneration. In peripheral neurons axotomy induces a large cohort of regeneration-associated genes (RAGs). The forced expression of some of these RAGs in injured neurons has some beneficial effect on axon regeneration, but the reported effects are rather small. Transcription factors (TFs) provide a promising class of RAGs. TFs are hubs in the regeneration-associated gene network, and potentially control the coordinate expression of many RAGs simultaneously. Here we discuss the use of combined experimental and computational methods to identify novel regeneration-associated TFs with a key role in initiating and maintaining the RAG-response in injured neurons. We propose that a relatively small number of hub TFs with multiple functional connections in the RAG network might provide attractive new targets for gene-based and/or pharmacological approaches to promote axon regeneration in the central nervous system.
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spelling pubmed-32221092011-11-28 A Gene Network Perspective on Axonal Regeneration van Kesteren, Ronald E. Mason, Matthew R. J. MacGillavry, Harold D. Smit, August B. Verhaagen, Joost Front Mol Neurosci Neuroscience The regenerative capacity of injured neurons in the central nervous system is limited due to the absence of a robust neuron-intrinsic injury-induced gene response that supports axon regeneration. In peripheral neurons axotomy induces a large cohort of regeneration-associated genes (RAGs). The forced expression of some of these RAGs in injured neurons has some beneficial effect on axon regeneration, but the reported effects are rather small. Transcription factors (TFs) provide a promising class of RAGs. TFs are hubs in the regeneration-associated gene network, and potentially control the coordinate expression of many RAGs simultaneously. Here we discuss the use of combined experimental and computational methods to identify novel regeneration-associated TFs with a key role in initiating and maintaining the RAG-response in injured neurons. We propose that a relatively small number of hub TFs with multiple functional connections in the RAG network might provide attractive new targets for gene-based and/or pharmacological approaches to promote axon regeneration in the central nervous system. Frontiers Research Foundation 2011-11-22 /pmc/articles/PMC3222109/ /pubmed/22125511 http://dx.doi.org/10.3389/fnmol.2011.00046 Text en Copyright © 2011 van Kesteren, Mason, MacGillavry, Smit and Verhaagen. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
spellingShingle Neuroscience
van Kesteren, Ronald E.
Mason, Matthew R. J.
MacGillavry, Harold D.
Smit, August B.
Verhaagen, Joost
A Gene Network Perspective on Axonal Regeneration
title A Gene Network Perspective on Axonal Regeneration
title_full A Gene Network Perspective on Axonal Regeneration
title_fullStr A Gene Network Perspective on Axonal Regeneration
title_full_unstemmed A Gene Network Perspective on Axonal Regeneration
title_short A Gene Network Perspective on Axonal Regeneration
title_sort gene network perspective on axonal regeneration
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222109/
https://www.ncbi.nlm.nih.gov/pubmed/22125511
http://dx.doi.org/10.3389/fnmol.2011.00046
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