A Gene Network Perspective on Axonal Regeneration
The regenerative capacity of injured neurons in the central nervous system is limited due to the absence of a robust neuron-intrinsic injury-induced gene response that supports axon regeneration. In peripheral neurons axotomy induces a large cohort of regeneration-associated genes (RAGs). The forced...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222109/ https://www.ncbi.nlm.nih.gov/pubmed/22125511 http://dx.doi.org/10.3389/fnmol.2011.00046 |
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author | van Kesteren, Ronald E. Mason, Matthew R. J. MacGillavry, Harold D. Smit, August B. Verhaagen, Joost |
author_facet | van Kesteren, Ronald E. Mason, Matthew R. J. MacGillavry, Harold D. Smit, August B. Verhaagen, Joost |
author_sort | van Kesteren, Ronald E. |
collection | PubMed |
description | The regenerative capacity of injured neurons in the central nervous system is limited due to the absence of a robust neuron-intrinsic injury-induced gene response that supports axon regeneration. In peripheral neurons axotomy induces a large cohort of regeneration-associated genes (RAGs). The forced expression of some of these RAGs in injured neurons has some beneficial effect on axon regeneration, but the reported effects are rather small. Transcription factors (TFs) provide a promising class of RAGs. TFs are hubs in the regeneration-associated gene network, and potentially control the coordinate expression of many RAGs simultaneously. Here we discuss the use of combined experimental and computational methods to identify novel regeneration-associated TFs with a key role in initiating and maintaining the RAG-response in injured neurons. We propose that a relatively small number of hub TFs with multiple functional connections in the RAG network might provide attractive new targets for gene-based and/or pharmacological approaches to promote axon regeneration in the central nervous system. |
format | Online Article Text |
id | pubmed-3222109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32221092011-11-28 A Gene Network Perspective on Axonal Regeneration van Kesteren, Ronald E. Mason, Matthew R. J. MacGillavry, Harold D. Smit, August B. Verhaagen, Joost Front Mol Neurosci Neuroscience The regenerative capacity of injured neurons in the central nervous system is limited due to the absence of a robust neuron-intrinsic injury-induced gene response that supports axon regeneration. In peripheral neurons axotomy induces a large cohort of regeneration-associated genes (RAGs). The forced expression of some of these RAGs in injured neurons has some beneficial effect on axon regeneration, but the reported effects are rather small. Transcription factors (TFs) provide a promising class of RAGs. TFs are hubs in the regeneration-associated gene network, and potentially control the coordinate expression of many RAGs simultaneously. Here we discuss the use of combined experimental and computational methods to identify novel regeneration-associated TFs with a key role in initiating and maintaining the RAG-response in injured neurons. We propose that a relatively small number of hub TFs with multiple functional connections in the RAG network might provide attractive new targets for gene-based and/or pharmacological approaches to promote axon regeneration in the central nervous system. Frontiers Research Foundation 2011-11-22 /pmc/articles/PMC3222109/ /pubmed/22125511 http://dx.doi.org/10.3389/fnmol.2011.00046 Text en Copyright © 2011 van Kesteren, Mason, MacGillavry, Smit and Verhaagen. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with. |
spellingShingle | Neuroscience van Kesteren, Ronald E. Mason, Matthew R. J. MacGillavry, Harold D. Smit, August B. Verhaagen, Joost A Gene Network Perspective on Axonal Regeneration |
title | A Gene Network Perspective on Axonal Regeneration |
title_full | A Gene Network Perspective on Axonal Regeneration |
title_fullStr | A Gene Network Perspective on Axonal Regeneration |
title_full_unstemmed | A Gene Network Perspective on Axonal Regeneration |
title_short | A Gene Network Perspective on Axonal Regeneration |
title_sort | gene network perspective on axonal regeneration |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222109/ https://www.ncbi.nlm.nih.gov/pubmed/22125511 http://dx.doi.org/10.3389/fnmol.2011.00046 |
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