MicroRNAs: tiny players with a big role in the pathogenesis of leukemias and lymphomas

MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) with important regulatory functions. After an initial phase, aimed at identifying whether a deregulation in miRNA expression occurred between hematologic malignancies and their normal counterparts, currently an increasing number of studies are fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Fanini, Francesca, Vannini, Ivan, Fabbri, Muller
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222241/
http://dx.doi.org/10.4081/hr.2009.e8
_version_ 1782217188506075136
author Fanini, Francesca
Vannini, Ivan
Fabbri, Muller
author_facet Fanini, Francesca
Vannini, Ivan
Fabbri, Muller
author_sort Fanini, Francesca
collection PubMed
description MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) with important regulatory functions. After an initial phase, aimed at identifying whether a deregulation in miRNA expression occurred between hematologic malignancies and their normal counterparts, currently an increasing number of studies are focusing on the functional significance of these aberrancies. The identification of miRNA targeted genes has cast a new light on the role of these tiny ncRNAs in human cancerogenesis, providing a new rationale to the observed diagnostic, prognostic and therapeutic implications of miRNA aberrant expression in human hematologic malignancies.
format Online
Article
Text
id pubmed-3222241
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher PAGEPress Publications
record_format MEDLINE/PubMed
spelling pubmed-32222412011-12-19 MicroRNAs: tiny players with a big role in the pathogenesis of leukemias and lymphomas Fanini, Francesca Vannini, Ivan Fabbri, Muller Hematol Rev Article MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) with important regulatory functions. After an initial phase, aimed at identifying whether a deregulation in miRNA expression occurred between hematologic malignancies and their normal counterparts, currently an increasing number of studies are focusing on the functional significance of these aberrancies. The identification of miRNA targeted genes has cast a new light on the role of these tiny ncRNAs in human cancerogenesis, providing a new rationale to the observed diagnostic, prognostic and therapeutic implications of miRNA aberrant expression in human hematologic malignancies. PAGEPress Publications 2009-05-26 /pmc/articles/PMC3222241/ http://dx.doi.org/10.4081/hr.2009.e8 Text en ©Copyright F. Fanini et al., 2009 This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0) Licensee PAGEPress, Italy
spellingShingle Article
Fanini, Francesca
Vannini, Ivan
Fabbri, Muller
MicroRNAs: tiny players with a big role in the pathogenesis of leukemias and lymphomas
title MicroRNAs: tiny players with a big role in the pathogenesis of leukemias and lymphomas
title_full MicroRNAs: tiny players with a big role in the pathogenesis of leukemias and lymphomas
title_fullStr MicroRNAs: tiny players with a big role in the pathogenesis of leukemias and lymphomas
title_full_unstemmed MicroRNAs: tiny players with a big role in the pathogenesis of leukemias and lymphomas
title_short MicroRNAs: tiny players with a big role in the pathogenesis of leukemias and lymphomas
title_sort micrornas: tiny players with a big role in the pathogenesis of leukemias and lymphomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222241/
http://dx.doi.org/10.4081/hr.2009.e8
work_keys_str_mv AT faninifrancesca micrornastinyplayerswithabigroleinthepathogenesisofleukemiasandlymphomas
AT vanniniivan micrornastinyplayerswithabigroleinthepathogenesisofleukemiasandlymphomas
AT fabbrimuller micrornastinyplayerswithabigroleinthepathogenesisofleukemiasandlymphomas

Ejemplares similares