Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter's syndrome

Klinefelter's syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a p...

Descripción completa

Detalles Bibliográficos
Autores principales: Slavcheva, Vanya, Lukanov, Tzvetan, Balatsenko, Gueorgui, Angelova, Svetlana, Antonov, Antonio, Bogdanov, Lachezar, Tsvetkov, Nikolay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222265/
https://www.ncbi.nlm.nih.gov/pubmed/22184514
http://dx.doi.org/10.4081/hr.2010.e11
_version_ 1782217193830744064
author Slavcheva, Vanya
Lukanov, Tzvetan
Balatsenko, Gueorgui
Angelova, Svetlana
Antonov, Antonio
Bogdanov, Lachezar
Tsvetkov, Nikolay
author_facet Slavcheva, Vanya
Lukanov, Tzvetan
Balatsenko, Gueorgui
Angelova, Svetlana
Antonov, Antonio
Bogdanov, Lachezar
Tsvetkov, Nikolay
author_sort Slavcheva, Vanya
collection PubMed
description Klinefelter's syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patient diagnosed with acute myelomonoblastic leukemia-M4 Eo (AML- M4), where by means of classic cytogenetics a karyotype was found corresponding to Klinefelter's syndrome. Three induction courses of polychemotherapy wermade, which led to remission of the disease, documented both flowcytometrically and cytogenetically.
format Online
Article
Text
id pubmed-3222265
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher PAGEPress Publications
record_format MEDLINE/PubMed
spelling pubmed-32222652011-12-19 Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter's syndrome Slavcheva, Vanya Lukanov, Tzvetan Balatsenko, Gueorgui Angelova, Svetlana Antonov, Antonio Bogdanov, Lachezar Tsvetkov, Nikolay Hematol Rep Case Report Klinefelter's syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patient diagnosed with acute myelomonoblastic leukemia-M4 Eo (AML- M4), where by means of classic cytogenetics a karyotype was found corresponding to Klinefelter's syndrome. Three induction courses of polychemotherapy wermade, which led to remission of the disease, documented both flowcytometrically and cytogenetically. PAGEPress Publications 2010-12-22 /pmc/articles/PMC3222265/ /pubmed/22184514 http://dx.doi.org/10.4081/hr.2010.e11 Text en ©Copyright V. Slavcheva et al., 2010 This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0). Licensee PAGEPress, Italy
spellingShingle Case Report
Slavcheva, Vanya
Lukanov, Tzvetan
Balatsenko, Gueorgui
Angelova, Svetlana
Antonov, Antonio
Bogdanov, Lachezar
Tsvetkov, Nikolay
Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter's syndrome
title Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter's syndrome
title_full Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter's syndrome
title_fullStr Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter's syndrome
title_full_unstemmed Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter's syndrome
title_short Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter's syndrome
title_sort clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with klinefelter's syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222265/
https://www.ncbi.nlm.nih.gov/pubmed/22184514
http://dx.doi.org/10.4081/hr.2010.e11
work_keys_str_mv AT slavchevavanya clinicalcaseofacutemyeloblasticleukemiawitht821q22q22inapatientwithklinefelterssyndrome
AT lukanovtzvetan clinicalcaseofacutemyeloblasticleukemiawitht821q22q22inapatientwithklinefelterssyndrome
AT balatsenkogueorgui clinicalcaseofacutemyeloblasticleukemiawitht821q22q22inapatientwithklinefelterssyndrome
AT angelovasvetlana clinicalcaseofacutemyeloblasticleukemiawitht821q22q22inapatientwithklinefelterssyndrome
AT antonovantonio clinicalcaseofacutemyeloblasticleukemiawitht821q22q22inapatientwithklinefelterssyndrome
AT bogdanovlachezar clinicalcaseofacutemyeloblasticleukemiawitht821q22q22inapatientwithklinefelterssyndrome
AT tsvetkovnikolay clinicalcaseofacutemyeloblasticleukemiawitht821q22q22inapatientwithklinefelterssyndrome

Ejemplares similares