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Serinol: small molecule - big impact
The amino alcohol serinol (2-amino-1,3-propanediol) has become a common intermediate for several chemical processes. Since the 1940s serinol was used as precursor for synthesis of synthetic antibiotics (chloramphenicol). In the last years, new scopes of applications were discovered. Serinol is used...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222319/ https://www.ncbi.nlm.nih.gov/pubmed/21906364 http://dx.doi.org/10.1186/2191-0855-1-12 |
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author | Andreeßen, Björn Steinbüchel, Alexander |
author_facet | Andreeßen, Björn Steinbüchel, Alexander |
author_sort | Andreeßen, Björn |
collection | PubMed |
description | The amino alcohol serinol (2-amino-1,3-propanediol) has become a common intermediate for several chemical processes. Since the 1940s serinol was used as precursor for synthesis of synthetic antibiotics (chloramphenicol). In the last years, new scopes of applications were discovered. Serinol is used for X-ray contrast agents, pharmaceuticals or for chemical sphingosine/ceramide synthesis. It can either be obtained by chemical processes based on 2-nitro-1,3-propanediol, dihydroxyacetone and ammonia, dihydroxyacetone oxime or 5-amino-1,3-dioxane, or biotechnological application of amino alcohol dehydrogenases (AMDH) or transaminases. This review provides a survey of synthesis, properties and applications for serinol. |
format | Online Article Text |
id | pubmed-3222319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer |
record_format | MEDLINE/PubMed |
spelling | pubmed-32223192011-12-16 Serinol: small molecule - big impact Andreeßen, Björn Steinbüchel, Alexander AMB Express Mini-Review The amino alcohol serinol (2-amino-1,3-propanediol) has become a common intermediate for several chemical processes. Since the 1940s serinol was used as precursor for synthesis of synthetic antibiotics (chloramphenicol). In the last years, new scopes of applications were discovered. Serinol is used for X-ray contrast agents, pharmaceuticals or for chemical sphingosine/ceramide synthesis. It can either be obtained by chemical processes based on 2-nitro-1,3-propanediol, dihydroxyacetone and ammonia, dihydroxyacetone oxime or 5-amino-1,3-dioxane, or biotechnological application of amino alcohol dehydrogenases (AMDH) or transaminases. This review provides a survey of synthesis, properties and applications for serinol. Springer 2011-06-13 /pmc/articles/PMC3222319/ /pubmed/21906364 http://dx.doi.org/10.1186/2191-0855-1-12 Text en Copyright ©2011 Andreeßen and Steinbüchel; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Mini-Review Andreeßen, Björn Steinbüchel, Alexander Serinol: small molecule - big impact |
title | Serinol: small molecule - big impact |
title_full | Serinol: small molecule - big impact |
title_fullStr | Serinol: small molecule - big impact |
title_full_unstemmed | Serinol: small molecule - big impact |
title_short | Serinol: small molecule - big impact |
title_sort | serinol: small molecule - big impact |
topic | Mini-Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222319/ https://www.ncbi.nlm.nih.gov/pubmed/21906364 http://dx.doi.org/10.1186/2191-0855-1-12 |
work_keys_str_mv | AT andreeßenbjorn serinolsmallmoleculebigimpact AT steinbuchelalexander serinolsmallmoleculebigimpact |