Cargando…

Serinol: small molecule - big impact

The amino alcohol serinol (2-amino-1,3-propanediol) has become a common intermediate for several chemical processes. Since the 1940s serinol was used as precursor for synthesis of synthetic antibiotics (chloramphenicol). In the last years, new scopes of applications were discovered. Serinol is used...

Descripción completa

Detalles Bibliográficos
Autores principales: Andreeßen, Björn, Steinbüchel, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222319/
https://www.ncbi.nlm.nih.gov/pubmed/21906364
http://dx.doi.org/10.1186/2191-0855-1-12
_version_ 1782217198701379584
author Andreeßen, Björn
Steinbüchel, Alexander
author_facet Andreeßen, Björn
Steinbüchel, Alexander
author_sort Andreeßen, Björn
collection PubMed
description The amino alcohol serinol (2-amino-1,3-propanediol) has become a common intermediate for several chemical processes. Since the 1940s serinol was used as precursor for synthesis of synthetic antibiotics (chloramphenicol). In the last years, new scopes of applications were discovered. Serinol is used for X-ray contrast agents, pharmaceuticals or for chemical sphingosine/ceramide synthesis. It can either be obtained by chemical processes based on 2-nitro-1,3-propanediol, dihydroxyacetone and ammonia, dihydroxyacetone oxime or 5-amino-1,3-dioxane, or biotechnological application of amino alcohol dehydrogenases (AMDH) or transaminases. This review provides a survey of synthesis, properties and applications for serinol.
format Online
Article
Text
id pubmed-3222319
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Springer
record_format MEDLINE/PubMed
spelling pubmed-32223192011-12-16 Serinol: small molecule - big impact Andreeßen, Björn Steinbüchel, Alexander AMB Express Mini-Review The amino alcohol serinol (2-amino-1,3-propanediol) has become a common intermediate for several chemical processes. Since the 1940s serinol was used as precursor for synthesis of synthetic antibiotics (chloramphenicol). In the last years, new scopes of applications were discovered. Serinol is used for X-ray contrast agents, pharmaceuticals or for chemical sphingosine/ceramide synthesis. It can either be obtained by chemical processes based on 2-nitro-1,3-propanediol, dihydroxyacetone and ammonia, dihydroxyacetone oxime or 5-amino-1,3-dioxane, or biotechnological application of amino alcohol dehydrogenases (AMDH) or transaminases. This review provides a survey of synthesis, properties and applications for serinol. Springer 2011-06-13 /pmc/articles/PMC3222319/ /pubmed/21906364 http://dx.doi.org/10.1186/2191-0855-1-12 Text en Copyright ©2011 Andreeßen and Steinbüchel; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini-Review
Andreeßen, Björn
Steinbüchel, Alexander
Serinol: small molecule - big impact
title Serinol: small molecule - big impact
title_full Serinol: small molecule - big impact
title_fullStr Serinol: small molecule - big impact
title_full_unstemmed Serinol: small molecule - big impact
title_short Serinol: small molecule - big impact
title_sort serinol: small molecule - big impact
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222319/
https://www.ncbi.nlm.nih.gov/pubmed/21906364
http://dx.doi.org/10.1186/2191-0855-1-12
work_keys_str_mv AT andreeßenbjorn serinolsmallmoleculebigimpact
AT steinbuchelalexander serinolsmallmoleculebigimpact