Hypochlorous Acid-Induced Heme Degradation from Lactoperoxidase as a Novel Mechanism of Free Iron Release and Tissue Injury in Inflammatory Diseases

Lactoperoxidase (LPO) is the major consumer of hydrogen peroxide (H(2)O(2)) in the airways through its ability to oxidize thiocyanate (SCN(−)) to produce hypothiocyanous acid, an antimicrobial agent. In nasal inflammatory diseases, such as cystic fibrosis, both LPO and myeloperoxidase (MPO), another...

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Detalles Bibliográficos
Autores principales: Souza, Carlos Eduardo A., Maitra, Dhiman, Saed, Ghassan M., Diamond, Michael P., Moura, Arlindo A., Pennathur, Subramaniam, Abu-Soud, Husam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222650/
https://www.ncbi.nlm.nih.gov/pubmed/22132121
http://dx.doi.org/10.1371/journal.pone.0027641

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