Modular protein-RNA interactions regulating mRNA metabolism: a role for NMR

Here we review the role played by transient interactions between multi-functional proteins and their RNA targets in the regulation of mRNA metabolism, and we describe the important function of NMR spectroscopy in the study of these systems. We place emphasis on a general approach for the study of di...

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Detalles Bibliográficos
Autores principales: Cukier, Cyprian D., Ramos, Andres
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222808/
https://www.ncbi.nlm.nih.gov/pubmed/21472430
http://dx.doi.org/10.1007/s00249-011-0698-z
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author Cukier, Cyprian D.
Ramos, Andres
author_facet Cukier, Cyprian D.
Ramos, Andres
author_sort Cukier, Cyprian D.
collection PubMed
description Here we review the role played by transient interactions between multi-functional proteins and their RNA targets in the regulation of mRNA metabolism, and we describe the important function of NMR spectroscopy in the study of these systems. We place emphasis on a general approach for the study of different features of modular multi-domain recognition that uses well-established NMR techniques and that has provided important advances in the general understanding of post-transcriptional regulation.
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spelling pubmed-32228082011-12-27 Modular protein-RNA interactions regulating mRNA metabolism: a role for NMR Cukier, Cyprian D. Ramos, Andres Eur Biophys J Review Here we review the role played by transient interactions between multi-functional proteins and their RNA targets in the regulation of mRNA metabolism, and we describe the important function of NMR spectroscopy in the study of these systems. We place emphasis on a general approach for the study of different features of modular multi-domain recognition that uses well-established NMR techniques and that has provided important advances in the general understanding of post-transcriptional regulation. Springer-Verlag 2011-04-07 2011 /pmc/articles/PMC3222808/ /pubmed/21472430 http://dx.doi.org/10.1007/s00249-011-0698-z Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Review
Cukier, Cyprian D.
Ramos, Andres
Modular protein-RNA interactions regulating mRNA metabolism: a role for NMR
title Modular protein-RNA interactions regulating mRNA metabolism: a role for NMR
title_full Modular protein-RNA interactions regulating mRNA metabolism: a role for NMR
title_fullStr Modular protein-RNA interactions regulating mRNA metabolism: a role for NMR
title_full_unstemmed Modular protein-RNA interactions regulating mRNA metabolism: a role for NMR
title_short Modular protein-RNA interactions regulating mRNA metabolism: a role for NMR
title_sort modular protein-rna interactions regulating mrna metabolism: a role for nmr
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222808/
https://www.ncbi.nlm.nih.gov/pubmed/21472430
http://dx.doi.org/10.1007/s00249-011-0698-z
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