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Modeling the pharmacodynamics of passive membrane permeability
Small molecule permeability through cellular membranes is critical to a better understanding of pharmacodynamics and the drug discovery endeavor. Such permeability may be estimated as a function of the free energy change of barrier crossing by invoking the barrier domain model, which posits that per...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Netherlands
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223344/ https://www.ncbi.nlm.nih.gov/pubmed/22042376 http://dx.doi.org/10.1007/s10822-011-9480-7 |