The Effect of N-nitrosodimethylamine (NDMA) on Bax and Mcl-1 Expression in Human Neutrophils

In the present study we examined a role of pro-apoptotic Bax and anti-apoptotic Mcl-1 proteins, participating in the regulation of intrinsic apoptosis pathway in human neutrophils (PMNs) exposed to N-nitrosodimethylamine (NDMA), the environmental xenobiotic. For the purpose comparison, the same stud...

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Detalles Bibliográficos
Autores principales: Jablonski, Jakub, Jablonska, Ewa, Leonik, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223349/
https://www.ncbi.nlm.nih.gov/pubmed/21947543
http://dx.doi.org/10.1007/s00128-011-0400-2
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author Jablonski, Jakub
Jablonska, Ewa
Leonik, Agnieszka
author_facet Jablonski, Jakub
Jablonska, Ewa
Leonik, Agnieszka
author_sort Jablonski, Jakub
collection PubMed
description In the present study we examined a role of pro-apoptotic Bax and anti-apoptotic Mcl-1 proteins, participating in the regulation of intrinsic apoptosis pathway in human neutrophils (PMNs) exposed to N-nitrosodimethylamine (NDMA), the environmental xenobiotic. For the purpose comparison, the same studies were conducted in autologous peripheral blood mononuclear cells (PBMCs). The production of cytochrome c by PMNs was also determined. A deficit of anti-apoptotic Mcl-1 and overexpression of the pro-apoptotic protein Bax suggest that the apoptosis process in human neutrophils exposed to NDMA is dependent on changes in the expression of these proteins. PMNs were more sensitive to NDMA than PBMCs.
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spelling pubmed-32233492011-12-27 The Effect of N-nitrosodimethylamine (NDMA) on Bax and Mcl-1 Expression in Human Neutrophils Jablonski, Jakub Jablonska, Ewa Leonik, Agnieszka Bull Environ Contam Toxicol Article In the present study we examined a role of pro-apoptotic Bax and anti-apoptotic Mcl-1 proteins, participating in the regulation of intrinsic apoptosis pathway in human neutrophils (PMNs) exposed to N-nitrosodimethylamine (NDMA), the environmental xenobiotic. For the purpose comparison, the same studies were conducted in autologous peripheral blood mononuclear cells (PBMCs). The production of cytochrome c by PMNs was also determined. A deficit of anti-apoptotic Mcl-1 and overexpression of the pro-apoptotic protein Bax suggest that the apoptosis process in human neutrophils exposed to NDMA is dependent on changes in the expression of these proteins. PMNs were more sensitive to NDMA than PBMCs. Springer-Verlag 2011-09-27 2011 /pmc/articles/PMC3223349/ /pubmed/21947543 http://dx.doi.org/10.1007/s00128-011-0400-2 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Jablonski, Jakub
Jablonska, Ewa
Leonik, Agnieszka
The Effect of N-nitrosodimethylamine (NDMA) on Bax and Mcl-1 Expression in Human Neutrophils
title The Effect of N-nitrosodimethylamine (NDMA) on Bax and Mcl-1 Expression in Human Neutrophils
title_full The Effect of N-nitrosodimethylamine (NDMA) on Bax and Mcl-1 Expression in Human Neutrophils
title_fullStr The Effect of N-nitrosodimethylamine (NDMA) on Bax and Mcl-1 Expression in Human Neutrophils
title_full_unstemmed The Effect of N-nitrosodimethylamine (NDMA) on Bax and Mcl-1 Expression in Human Neutrophils
title_short The Effect of N-nitrosodimethylamine (NDMA) on Bax and Mcl-1 Expression in Human Neutrophils
title_sort effect of n-nitrosodimethylamine (ndma) on bax and mcl-1 expression in human neutrophils
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223349/
https://www.ncbi.nlm.nih.gov/pubmed/21947543
http://dx.doi.org/10.1007/s00128-011-0400-2
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