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Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations
There is emerging evidence that people with successfully treated HIV infection age prematurely leading to progressive multi-organ disease (1), but the reasons for this are not known. Here we show that patients treated with commonly used nucleoside analog anti-retroviral drugs (NRTIs) progressively a...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223397/ https://www.ncbi.nlm.nih.gov/pubmed/21706004 http://dx.doi.org/10.1038/ng.863 |