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Postcardiac arrest syndrome: from immediate resuscitation to long-term outcome

The prognosis for postcardiac arrest patients remains very bleak, not only because of anoxic-ischemic neurological damage, but also because of the "postcardiac arrest syndrome," a phenomenon often severe enough to cause death before any neurological evaluation. This syndrome includes all c...

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Autores principales: Mongardon, Nicolas, Dumas, Florence, Ricome, Sylvie, Grimaldi, David, Hissem, Tarik, Pène, Frédéric, Cariou, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223497/
https://www.ncbi.nlm.nih.gov/pubmed/22053891
http://dx.doi.org/10.1186/2110-5820-1-45
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author Mongardon, Nicolas
Dumas, Florence
Ricome, Sylvie
Grimaldi, David
Hissem, Tarik
Pène, Frédéric
Cariou, Alain
author_facet Mongardon, Nicolas
Dumas, Florence
Ricome, Sylvie
Grimaldi, David
Hissem, Tarik
Pène, Frédéric
Cariou, Alain
author_sort Mongardon, Nicolas
collection PubMed
description The prognosis for postcardiac arrest patients remains very bleak, not only because of anoxic-ischemic neurological damage, but also because of the "postcardiac arrest syndrome," a phenomenon often severe enough to cause death before any neurological evaluation. This syndrome includes all clinical and biological manifestations related to the phenomenon of global ischemia-reperfusion triggered by cardiac arrest and return of spontaneous circulation. The main component of the postcardiac arrest syndrome is an early but severe cardiocirculatory dysfunction that may lead to multiple organ failure and death. Cardiovascular support relies on conventional medical and mechanical treatment of circulatory failure. Hemodynamic stabilization is a major objective to limit secondary brain insult. When the cause of cardiac arrest is related to myocardial infarction, percutaneous coronary revascularization is associated with improved prognosis; early angiographic exploration should then be discussed when there is no obvious extracardiac cause. Therapeutic hypothermia is now the cornerstone of postanoxic cerebral protection. Its widespread use is clearly recommended, with a favorable risk-benefit ratio in selected population. Neuroprotection also is based on the prevention of secondary cerebral damages, pending the results of ongoing therapeutic evaluations regarding the potential efficiency of new therapeutic drugs.
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spelling pubmed-32234972011-12-16 Postcardiac arrest syndrome: from immediate resuscitation to long-term outcome Mongardon, Nicolas Dumas, Florence Ricome, Sylvie Grimaldi, David Hissem, Tarik Pène, Frédéric Cariou, Alain Ann Intensive Care Review The prognosis for postcardiac arrest patients remains very bleak, not only because of anoxic-ischemic neurological damage, but also because of the "postcardiac arrest syndrome," a phenomenon often severe enough to cause death before any neurological evaluation. This syndrome includes all clinical and biological manifestations related to the phenomenon of global ischemia-reperfusion triggered by cardiac arrest and return of spontaneous circulation. The main component of the postcardiac arrest syndrome is an early but severe cardiocirculatory dysfunction that may lead to multiple organ failure and death. Cardiovascular support relies on conventional medical and mechanical treatment of circulatory failure. Hemodynamic stabilization is a major objective to limit secondary brain insult. When the cause of cardiac arrest is related to myocardial infarction, percutaneous coronary revascularization is associated with improved prognosis; early angiographic exploration should then be discussed when there is no obvious extracardiac cause. Therapeutic hypothermia is now the cornerstone of postanoxic cerebral protection. Its widespread use is clearly recommended, with a favorable risk-benefit ratio in selected population. Neuroprotection also is based on the prevention of secondary cerebral damages, pending the results of ongoing therapeutic evaluations regarding the potential efficiency of new therapeutic drugs. Springer 2011-11-03 /pmc/articles/PMC3223497/ /pubmed/22053891 http://dx.doi.org/10.1186/2110-5820-1-45 Text en Copyright ©2011 Mongardon et al; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Mongardon, Nicolas
Dumas, Florence
Ricome, Sylvie
Grimaldi, David
Hissem, Tarik
Pène, Frédéric
Cariou, Alain
Postcardiac arrest syndrome: from immediate resuscitation to long-term outcome
title Postcardiac arrest syndrome: from immediate resuscitation to long-term outcome
title_full Postcardiac arrest syndrome: from immediate resuscitation to long-term outcome
title_fullStr Postcardiac arrest syndrome: from immediate resuscitation to long-term outcome
title_full_unstemmed Postcardiac arrest syndrome: from immediate resuscitation to long-term outcome
title_short Postcardiac arrest syndrome: from immediate resuscitation to long-term outcome
title_sort postcardiac arrest syndrome: from immediate resuscitation to long-term outcome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223497/
https://www.ncbi.nlm.nih.gov/pubmed/22053891
http://dx.doi.org/10.1186/2110-5820-1-45
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