Long-term fenofibrate treatment impaired glucose-stimulated insulin secretion and up-regulated pancreatic NF-kappa B and iNOS expression in monosodium glutamate-induced obese rats: Is that a latent disadvantage?

BACKGROUND: Fenofibrate, a PPAR alpha agonist, has been widely used in clinics as lipid-regulating agent. PPAR alpha is known to be expressed in many organs including pancreatic beta cells and regulate genes involved in fatty acid metabolism. Some reports based on cell lines or animals have provided...

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Detalles Bibliográficos
Autores principales: Liu, Shuai-nan, Liu, Quan, Li, Lin-yi, Huan, Yi, Sun, Su-juan, Shen, Zhu-fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223503/
https://www.ncbi.nlm.nih.gov/pubmed/21999347
http://dx.doi.org/10.1186/1479-5876-9-176

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