Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells

PIM1 kinase and MYC are commonly co-expressed in human prostate cancer and synergize to induce rapidly progressing prostate cancer in mouse models. Deficiency of the Pim kinase genes is well tolerated in vivo, suggesting that PIM1 inhibition might offer an attractive therapeutic modality for prostat...

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Detalles Bibliográficos
Autores principales: Wang, Jie, Anderson, Philip D., Luo, Weifeng, Gius, David, Roh, Meejeon, Abdulkadir, Sarki A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223544/
https://www.ncbi.nlm.nih.gov/pubmed/21860423
http://dx.doi.org/10.1038/onc.2011.371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223544/
https://www.ncbi.nlm.nih.gov/pubmed/21860423
http://dx.doi.org/10.1038/onc.2011.371

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