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Automatic radiographic quantification of hand osteoarthritis; accuracy and sensitivity to change in joint space width in a phantom and cadaver study

OBJECTIVE: To validate a newly developed quantification method that automatically detects and quantifies the joint space width (JSW) in hand radiographs. Repeatability, accuracy and sensitivity to changes in JSW were determined. The influence of joint location and joint shape on the measurements was...

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Autores principales: Huétink, Kasper, van ’t Klooster, Ronald, Kaptein, Bart L., Watt, Iain, Kloppenburg, Margreet, Nelissen, Rob G. H. H., Reiber, Johan H. C., Stoel, Berend C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223586/
https://www.ncbi.nlm.nih.gov/pubmed/21311883
http://dx.doi.org/10.1007/s00256-011-1110-x
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author Huétink, Kasper
van ’t Klooster, Ronald
Kaptein, Bart L.
Watt, Iain
Kloppenburg, Margreet
Nelissen, Rob G. H. H.
Reiber, Johan H. C.
Stoel, Berend C.
author_facet Huétink, Kasper
van ’t Klooster, Ronald
Kaptein, Bart L.
Watt, Iain
Kloppenburg, Margreet
Nelissen, Rob G. H. H.
Reiber, Johan H. C.
Stoel, Berend C.
author_sort Huétink, Kasper
collection PubMed
description OBJECTIVE: To validate a newly developed quantification method that automatically detects and quantifies the joint space width (JSW) in hand radiographs. Repeatability, accuracy and sensitivity to changes in JSW were determined. The influence of joint location and joint shape on the measurements was tested. METHODS: A mechanical micrometer set-up was developed to define and adjust the true JSW in an acrylic phantom joint and in human cadaver-derived phalangeal joints. Radiographic measurements of the JSW were compared to the true JSW. Repeatability, systematic error (accuracy) and sensitivity (defined as the smallest detectable difference (SDD)) were determined. The influence of joint position on the JSW measurement was assessed by varying the location of the acrylic phantom on the X-ray detector with respect to the X-ray beam and the influence of joint shape was determined by using morphologically different human cadaver joints. RESULTS: The mean systematic error was 0.052 mm in the phantom joint and 0.210 mm in the cadaver experiment. In the phantom experiments, the repeatability was high (SDD = 0.028 mm), but differed slightly between joint locations (p = 0.046), and a change in JSW of 0.037 mm could be detected. Dependent of the joint shape in the cadaver hand, a change in JSW between 0.018 and 0.047 mm could be detected. CONCLUSIONS: The automatic quantification method is sensitive to small changes in JSW. Considering the published data of JSW decline in the normal and osteoarthritic population, the first signs of OA progression with this method can be detected within 1 or 2 years.
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spelling pubmed-32235862011-12-27 Automatic radiographic quantification of hand osteoarthritis; accuracy and sensitivity to change in joint space width in a phantom and cadaver study Huétink, Kasper van ’t Klooster, Ronald Kaptein, Bart L. Watt, Iain Kloppenburg, Margreet Nelissen, Rob G. H. H. Reiber, Johan H. C. Stoel, Berend C. Skeletal Radiol Scientific Article OBJECTIVE: To validate a newly developed quantification method that automatically detects and quantifies the joint space width (JSW) in hand radiographs. Repeatability, accuracy and sensitivity to changes in JSW were determined. The influence of joint location and joint shape on the measurements was tested. METHODS: A mechanical micrometer set-up was developed to define and adjust the true JSW in an acrylic phantom joint and in human cadaver-derived phalangeal joints. Radiographic measurements of the JSW were compared to the true JSW. Repeatability, systematic error (accuracy) and sensitivity (defined as the smallest detectable difference (SDD)) were determined. The influence of joint position on the JSW measurement was assessed by varying the location of the acrylic phantom on the X-ray detector with respect to the X-ray beam and the influence of joint shape was determined by using morphologically different human cadaver joints. RESULTS: The mean systematic error was 0.052 mm in the phantom joint and 0.210 mm in the cadaver experiment. In the phantom experiments, the repeatability was high (SDD = 0.028 mm), but differed slightly between joint locations (p = 0.046), and a change in JSW of 0.037 mm could be detected. Dependent of the joint shape in the cadaver hand, a change in JSW between 0.018 and 0.047 mm could be detected. CONCLUSIONS: The automatic quantification method is sensitive to small changes in JSW. Considering the published data of JSW decline in the normal and osteoarthritic population, the first signs of OA progression with this method can be detected within 1 or 2 years. Springer-Verlag 2011-02-11 2012 /pmc/articles/PMC3223586/ /pubmed/21311883 http://dx.doi.org/10.1007/s00256-011-1110-x Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Scientific Article
Huétink, Kasper
van ’t Klooster, Ronald
Kaptein, Bart L.
Watt, Iain
Kloppenburg, Margreet
Nelissen, Rob G. H. H.
Reiber, Johan H. C.
Stoel, Berend C.
Automatic radiographic quantification of hand osteoarthritis; accuracy and sensitivity to change in joint space width in a phantom and cadaver study
title Automatic radiographic quantification of hand osteoarthritis; accuracy and sensitivity to change in joint space width in a phantom and cadaver study
title_full Automatic radiographic quantification of hand osteoarthritis; accuracy and sensitivity to change in joint space width in a phantom and cadaver study
title_fullStr Automatic radiographic quantification of hand osteoarthritis; accuracy and sensitivity to change in joint space width in a phantom and cadaver study
title_full_unstemmed Automatic radiographic quantification of hand osteoarthritis; accuracy and sensitivity to change in joint space width in a phantom and cadaver study
title_short Automatic radiographic quantification of hand osteoarthritis; accuracy and sensitivity to change in joint space width in a phantom and cadaver study
title_sort automatic radiographic quantification of hand osteoarthritis; accuracy and sensitivity to change in joint space width in a phantom and cadaver study
topic Scientific Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223586/
https://www.ncbi.nlm.nih.gov/pubmed/21311883
http://dx.doi.org/10.1007/s00256-011-1110-x
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