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Streptococcus suis, an Emerging Drug-Resistant Animal and Human Pathogen
Streptococcus suis, a major porcine pathogen, has been receiving growing attention not only for its role in severe and increasingly reported infections in humans, but also for its involvement in drug resistance. Recent studies and the analysis of sequenced genomes have been providing important insig...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223616/ https://www.ncbi.nlm.nih.gov/pubmed/22275909 http://dx.doi.org/10.3389/fmicb.2011.00235 |
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author | Palmieri, Claudio Varaldo, Pietro E. Facinelli, Bruna |
author_facet | Palmieri, Claudio Varaldo, Pietro E. Facinelli, Bruna |
author_sort | Palmieri, Claudio |
collection | PubMed |
description | Streptococcus suis, a major porcine pathogen, has been receiving growing attention not only for its role in severe and increasingly reported infections in humans, but also for its involvement in drug resistance. Recent studies and the analysis of sequenced genomes have been providing important insights into the S. suis resistome, and have resulted in the identification of resistance determinants for tetracyclines, macrolides, aminoglycosides, chloramphenicol, antifolate drugs, streptothricin, and cadmium salts. Resistance gene-carrying genetic elements described so far include integrative and conjugative elements, transposons, genomic islands, phages, and chimeric elements. Some of these elements are similar to those reported in major streptococcal pathogens such as Streptococcus pyogenes, Streptococcus pneumoniae, and Streptococcus agalactiae and share the same chromosomal insertion sites. The available information strongly suggests that S. suis is an important antibiotic resistance reservoir that can contribute to the spread of resistance genes to the above-mentioned streptococci. S. suis is thus a paradigmatic example of possible intersections between animal and human resistomes. |
format | Online Article Text |
id | pubmed-3223616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32236162012-01-24 Streptococcus suis, an Emerging Drug-Resistant Animal and Human Pathogen Palmieri, Claudio Varaldo, Pietro E. Facinelli, Bruna Front Microbiol Microbiology Streptococcus suis, a major porcine pathogen, has been receiving growing attention not only for its role in severe and increasingly reported infections in humans, but also for its involvement in drug resistance. Recent studies and the analysis of sequenced genomes have been providing important insights into the S. suis resistome, and have resulted in the identification of resistance determinants for tetracyclines, macrolides, aminoglycosides, chloramphenicol, antifolate drugs, streptothricin, and cadmium salts. Resistance gene-carrying genetic elements described so far include integrative and conjugative elements, transposons, genomic islands, phages, and chimeric elements. Some of these elements are similar to those reported in major streptococcal pathogens such as Streptococcus pyogenes, Streptococcus pneumoniae, and Streptococcus agalactiae and share the same chromosomal insertion sites. The available information strongly suggests that S. suis is an important antibiotic resistance reservoir that can contribute to the spread of resistance genes to the above-mentioned streptococci. S. suis is thus a paradigmatic example of possible intersections between animal and human resistomes. Frontiers Research Foundation 2011-11-25 /pmc/articles/PMC3223616/ /pubmed/22275909 http://dx.doi.org/10.3389/fmicb.2011.00235 Text en Copyright © 2011 Palmieri, Varaldo and Facinelli. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with. |
spellingShingle | Microbiology Palmieri, Claudio Varaldo, Pietro E. Facinelli, Bruna Streptococcus suis, an Emerging Drug-Resistant Animal and Human Pathogen |
title | Streptococcus suis, an Emerging Drug-Resistant Animal and Human Pathogen |
title_full | Streptococcus suis, an Emerging Drug-Resistant Animal and Human Pathogen |
title_fullStr | Streptococcus suis, an Emerging Drug-Resistant Animal and Human Pathogen |
title_full_unstemmed | Streptococcus suis, an Emerging Drug-Resistant Animal and Human Pathogen |
title_short | Streptococcus suis, an Emerging Drug-Resistant Animal and Human Pathogen |
title_sort | streptococcus suis, an emerging drug-resistant animal and human pathogen |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223616/ https://www.ncbi.nlm.nih.gov/pubmed/22275909 http://dx.doi.org/10.3389/fmicb.2011.00235 |
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