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Malaria and pre-eclampsia in an area with unstable malaria transmission in Central Sudan
BACKGROUND: Placental malaria and pre-eclampsia occur frequently in women in tropics and are leading causes of maternal and perinatal morbidities and mortality. Few data exist concerning the interaction between placental malaria and pre-eclampsia. METHODS: A case control study was conducted in Medan...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224261/ https://www.ncbi.nlm.nih.gov/pubmed/21899731 http://dx.doi.org/10.1186/1475-2875-10-258 |
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author | Adam, Ishag Elhassan, Elhassan M Mohmmed, Ahmed A Salih, Magdi M Elbashir, Mustafa I |
author_facet | Adam, Ishag Elhassan, Elhassan M Mohmmed, Ahmed A Salih, Magdi M Elbashir, Mustafa I |
author_sort | Adam, Ishag |
collection | PubMed |
description | BACKGROUND: Placental malaria and pre-eclampsia occur frequently in women in tropics and are leading causes of maternal and perinatal morbidities and mortality. Few data exist concerning the interaction between placental malaria and pre-eclampsia. METHODS: A case control study was conducted in Medani Hospital, which locates in an area of unstable malaria transmission in Central Sudan. Case (N = 143) were women with pre-eclampsia, which was defined as systolic blood presure≥140 mm Hg or diastolic blood pressure ≥ 90 mm Hg and proteinuria. Controls were parturient women (N = 143) without any blood pressure values > 139/89 mm Hg or proteinuria. Obstetrical and medical characteristics were gathered from both groups through structured questionnaires. Placental histopathology examinations for malaria were performed. RESULTS: Twenty-eight (19.6%) vs. 16 (11.2%); P = 0.04 of the cases vs. controls, had placental malaria infections. Five (2%), 1 (2%) and 22 (28.0%) vs. 1, 2 and 13 of the placentae showed acute, chronic and past infection on histopathology examination in the two groups respectively, while 115 (80.4%) vs.127 (88.8%) of them showed no infection, P = 0.04. In multivariate analysis, while there were no associations between age, parity, educational level, lack of antenatal care, blood groups and body mass index and pre-eclampsia; family history of hypertension and placental malaria (OR = 2.3, 95% CI = 1.0-5.2; P = 0.04) were significantly associated with pre-eclampsia. CONCLUSION: Placental malaria was associated with pre-eclampsia. Further research is needed. |
format | Online Article Text |
id | pubmed-3224261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32242612011-11-27 Malaria and pre-eclampsia in an area with unstable malaria transmission in Central Sudan Adam, Ishag Elhassan, Elhassan M Mohmmed, Ahmed A Salih, Magdi M Elbashir, Mustafa I Malar J Research BACKGROUND: Placental malaria and pre-eclampsia occur frequently in women in tropics and are leading causes of maternal and perinatal morbidities and mortality. Few data exist concerning the interaction between placental malaria and pre-eclampsia. METHODS: A case control study was conducted in Medani Hospital, which locates in an area of unstable malaria transmission in Central Sudan. Case (N = 143) were women with pre-eclampsia, which was defined as systolic blood presure≥140 mm Hg or diastolic blood pressure ≥ 90 mm Hg and proteinuria. Controls were parturient women (N = 143) without any blood pressure values > 139/89 mm Hg or proteinuria. Obstetrical and medical characteristics were gathered from both groups through structured questionnaires. Placental histopathology examinations for malaria were performed. RESULTS: Twenty-eight (19.6%) vs. 16 (11.2%); P = 0.04 of the cases vs. controls, had placental malaria infections. Five (2%), 1 (2%) and 22 (28.0%) vs. 1, 2 and 13 of the placentae showed acute, chronic and past infection on histopathology examination in the two groups respectively, while 115 (80.4%) vs.127 (88.8%) of them showed no infection, P = 0.04. In multivariate analysis, while there were no associations between age, parity, educational level, lack of antenatal care, blood groups and body mass index and pre-eclampsia; family history of hypertension and placental malaria (OR = 2.3, 95% CI = 1.0-5.2; P = 0.04) were significantly associated with pre-eclampsia. CONCLUSION: Placental malaria was associated with pre-eclampsia. Further research is needed. BioMed Central 2011-09-07 /pmc/articles/PMC3224261/ /pubmed/21899731 http://dx.doi.org/10.1186/1475-2875-10-258 Text en Copyright ©2011 Adam et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Adam, Ishag Elhassan, Elhassan M Mohmmed, Ahmed A Salih, Magdi M Elbashir, Mustafa I Malaria and pre-eclampsia in an area with unstable malaria transmission in Central Sudan |
title | Malaria and pre-eclampsia in an area with unstable malaria transmission in Central Sudan |
title_full | Malaria and pre-eclampsia in an area with unstable malaria transmission in Central Sudan |
title_fullStr | Malaria and pre-eclampsia in an area with unstable malaria transmission in Central Sudan |
title_full_unstemmed | Malaria and pre-eclampsia in an area with unstable malaria transmission in Central Sudan |
title_short | Malaria and pre-eclampsia in an area with unstable malaria transmission in Central Sudan |
title_sort | malaria and pre-eclampsia in an area with unstable malaria transmission in central sudan |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224261/ https://www.ncbi.nlm.nih.gov/pubmed/21899731 http://dx.doi.org/10.1186/1475-2875-10-258 |
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