Determination of Doxazosin Mesylate in Tablets by RP-HPLC

A simple, precise and rapid RP-HPLC method was developed for the determination of doxazosin mesylate in pharmaceutical formulations. The method was carried out on a Chromolith RP-C(18) column using a mixture of potassium phosphate buffer and methanol (40:60 v/v) and detection was done at 251 nm. The...

Descripción completa

Detalles Bibliográficos
Autores principales: Dhanya, B., Suganthi, A., Sen, A. K., Sahoo, U., Seth, A. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224404/
https://www.ncbi.nlm.nih.gov/pubmed/22131637
http://dx.doi.org/10.4103/0250-474X.89772
Descripción
Sumario:A simple, precise and rapid RP-HPLC method was developed for the determination of doxazosin mesylate in pharmaceutical formulations. The method was carried out on a Chromolith RP-C(18) column using a mixture of potassium phosphate buffer and methanol (40:60 v/v) and detection was done at 251 nm. The linearity range was 1-5 μg/ml. The retention time of the drug was 3.8 min. The LOD and LOQ were found to be 0.1 μg/ml and 0.5 μg/ml, respectively.

Ejemplares similares