Determination of Doxazosin Mesylate in Tablets by RP-HPLC

A simple, precise and rapid RP-HPLC method was developed for the determination of doxazosin mesylate in pharmaceutical formulations. The method was carried out on a Chromolith RP-C(18) column using a mixture of potassium phosphate buffer and methanol (40:60 v/v) and detection was done at 251 nm. The...

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Detalles Bibliográficos
Autores principales: Dhanya, B., Suganthi, A., Sen, A. K., Sahoo, U., Seth, A. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224404/
https://www.ncbi.nlm.nih.gov/pubmed/22131637
http://dx.doi.org/10.4103/0250-474X.89772
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author Dhanya, B.
Suganthi, A.
Sen, A. K.
Sahoo, U.
Seth, A. K.
author_facet Dhanya, B.
Suganthi, A.
Sen, A. K.
Sahoo, U.
Seth, A. K.
author_sort Dhanya, B.
collection PubMed
description A simple, precise and rapid RP-HPLC method was developed for the determination of doxazosin mesylate in pharmaceutical formulations. The method was carried out on a Chromolith RP-C(18) column using a mixture of potassium phosphate buffer and methanol (40:60 v/v) and detection was done at 251 nm. The linearity range was 1-5 μg/ml. The retention time of the drug was 3.8 min. The LOD and LOQ were found to be 0.1 μg/ml and 0.5 μg/ml, respectively.
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spelling pubmed-32244042011-11-30 Determination of Doxazosin Mesylate in Tablets by RP-HPLC Dhanya, B. Suganthi, A. Sen, A. K. Sahoo, U. Seth, A. K. Indian J Pharm Sci Short Communications A simple, precise and rapid RP-HPLC method was developed for the determination of doxazosin mesylate in pharmaceutical formulations. The method was carried out on a Chromolith RP-C(18) column using a mixture of potassium phosphate buffer and methanol (40:60 v/v) and detection was done at 251 nm. The linearity range was 1-5 μg/ml. The retention time of the drug was 3.8 min. The LOD and LOQ were found to be 0.1 μg/ml and 0.5 μg/ml, respectively. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3224404/ /pubmed/22131637 http://dx.doi.org/10.4103/0250-474X.89772 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Dhanya, B.
Suganthi, A.
Sen, A. K.
Sahoo, U.
Seth, A. K.
Determination of Doxazosin Mesylate in Tablets by RP-HPLC
title Determination of Doxazosin Mesylate in Tablets by RP-HPLC
title_full Determination of Doxazosin Mesylate in Tablets by RP-HPLC
title_fullStr Determination of Doxazosin Mesylate in Tablets by RP-HPLC
title_full_unstemmed Determination of Doxazosin Mesylate in Tablets by RP-HPLC
title_short Determination of Doxazosin Mesylate in Tablets by RP-HPLC
title_sort determination of doxazosin mesylate in tablets by rp-hplc
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224404/
https://www.ncbi.nlm.nih.gov/pubmed/22131637
http://dx.doi.org/10.4103/0250-474X.89772
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