Visible Spectrophotometric Method for the Determination of Aripiprazole in Tablets

A simple, accurate and economic spectrophotometric method for the determination of aripiprazole in tablet formulation is proposed. In the present method acidic solution of the aripiprazole formed colored ion-association complexes with bromocresol green, soluble in chloroform. Yellowish orange chromo...

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Detalles Bibliográficos
Autores principales: Jain, R., Kashaw, S. K., Jain, Rishab, Mishra, P., Kohli, D. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224414/
https://www.ncbi.nlm.nih.gov/pubmed/22131625
http://dx.doi.org/10.4103/0250-474X.89760
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author Jain, R.
Kashaw, S. K.
Jain, Rishab
Mishra, P.
Kohli, D. V.
author_facet Jain, R.
Kashaw, S. K.
Jain, Rishab
Mishra, P.
Kohli, D. V.
author_sort Jain, R.
collection PubMed
description A simple, accurate and economic spectrophotometric method for the determination of aripiprazole in tablet formulation is proposed. In the present method acidic solution of the aripiprazole formed colored ion-association complexes with bromocresol green, soluble in chloroform. Yellowish orange chromogen showed λ(max) at 414 nm and obeyed Beer's law in the concentration range of 10-60 μg/ml. Statistical analysis and recovery studies validated the method. The proposed method is rapid, precise and accurate and can be applied for the routine estimation of aripiprazole in the laboratory.
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spelling pubmed-32244142011-11-30 Visible Spectrophotometric Method for the Determination of Aripiprazole in Tablets Jain, R. Kashaw, S. K. Jain, Rishab Mishra, P. Kohli, D. V. Indian J Pharm Sci Short Communication A simple, accurate and economic spectrophotometric method for the determination of aripiprazole in tablet formulation is proposed. In the present method acidic solution of the aripiprazole formed colored ion-association complexes with bromocresol green, soluble in chloroform. Yellowish orange chromogen showed λ(max) at 414 nm and obeyed Beer's law in the concentration range of 10-60 μg/ml. Statistical analysis and recovery studies validated the method. The proposed method is rapid, precise and accurate and can be applied for the routine estimation of aripiprazole in the laboratory. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3224414/ /pubmed/22131625 http://dx.doi.org/10.4103/0250-474X.89760 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Jain, R.
Kashaw, S. K.
Jain, Rishab
Mishra, P.
Kohli, D. V.
Visible Spectrophotometric Method for the Determination of Aripiprazole in Tablets
title Visible Spectrophotometric Method for the Determination of Aripiprazole in Tablets
title_full Visible Spectrophotometric Method for the Determination of Aripiprazole in Tablets
title_fullStr Visible Spectrophotometric Method for the Determination of Aripiprazole in Tablets
title_full_unstemmed Visible Spectrophotometric Method for the Determination of Aripiprazole in Tablets
title_short Visible Spectrophotometric Method for the Determination of Aripiprazole in Tablets
title_sort visible spectrophotometric method for the determination of aripiprazole in tablets
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224414/
https://www.ncbi.nlm.nih.gov/pubmed/22131625
http://dx.doi.org/10.4103/0250-474X.89760
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