Isolation and Characterization of Impurities Present in 8-Chlorotheophylline

A simple isocratic reversed phase high performance liquid chromatography was used to separate three impurities present in the sample of 8-chlorotheophylline. LC-MS was used for the characterization of impurities. Based on mass spectral data, the structures of these impurities were characterized as 3...

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Detalles Bibliográficos
Autores principales: Desai, Sonal, Patel, Archita, Gabhe, S. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224416/
https://www.ncbi.nlm.nih.gov/pubmed/22131627
http://dx.doi.org/10.4103/0250-474X.89762
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author Desai, Sonal
Patel, Archita
Gabhe, S. Y.
author_facet Desai, Sonal
Patel, Archita
Gabhe, S. Y.
author_sort Desai, Sonal
collection PubMed
description A simple isocratic reversed phase high performance liquid chromatography was used to separate three impurities present in the sample of 8-chlorotheophylline. LC-MS was used for the characterization of impurities. Based on mass spectral data, the structures of these impurities were characterized as 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (impurity I), 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione (impurity II) and isomer of 8-chloro-1,3-dimethyl-2,6(3H,1H)-purinedione (impurity III).
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spelling pubmed-32244162011-11-30 Isolation and Characterization of Impurities Present in 8-Chlorotheophylline Desai, Sonal Patel, Archita Gabhe, S. Y. Indian J Pharm Sci Short Communications A simple isocratic reversed phase high performance liquid chromatography was used to separate three impurities present in the sample of 8-chlorotheophylline. LC-MS was used for the characterization of impurities. Based on mass spectral data, the structures of these impurities were characterized as 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (impurity I), 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione (impurity II) and isomer of 8-chloro-1,3-dimethyl-2,6(3H,1H)-purinedione (impurity III). Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3224416/ /pubmed/22131627 http://dx.doi.org/10.4103/0250-474X.89762 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Desai, Sonal
Patel, Archita
Gabhe, S. Y.
Isolation and Characterization of Impurities Present in 8-Chlorotheophylline
title Isolation and Characterization of Impurities Present in 8-Chlorotheophylline
title_full Isolation and Characterization of Impurities Present in 8-Chlorotheophylline
title_fullStr Isolation and Characterization of Impurities Present in 8-Chlorotheophylline
title_full_unstemmed Isolation and Characterization of Impurities Present in 8-Chlorotheophylline
title_short Isolation and Characterization of Impurities Present in 8-Chlorotheophylline
title_sort isolation and characterization of impurities present in 8-chlorotheophylline
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224416/
https://www.ncbi.nlm.nih.gov/pubmed/22131627
http://dx.doi.org/10.4103/0250-474X.89762
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