Cargando…

Nitric oxide protects the heart from ischemia-induced apoptosis and mitochondrial damage via protein kinase G mediated blockage of permeability transition and cytochrome c release

BACKGROUND: Heart ischemia can rapidly induce apoptosis and mitochondrial dysfunction via mitochondrial permeability transition-induced cytochrome c release. We tested whether nitric oxide (NO) can block this damage in isolated rat heart, and, if so, by what mechanisms. METHODS: Hearts were perfused...

Descripción completa

Detalles Bibliográficos
Autores principales:	Borutaite, Vilmante, Morkuniene, Ramune, Arandarcikaite, Odeta, Jekabsone, Aiste, Barauskaite, Jurgita, Brown, Guy C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224577/ https://www.ncbi.nlm.nih.gov/pubmed/19671187 http://dx.doi.org/10.1186/1423-0127-16-70

Ejemplares similares

Comparison of Effects of Metformin, Phenformin, and Inhibitors of Mitochondrial Complex I on Mitochondrial Permeability Transition and Ischemic Brain Injury
por: Skemiene, Kristina, et al.
Publicado: (2020)

The Role of Intracellular Ca(2+) and Mitochondrial ROS in Small Aβ(1-42) Oligomer-Induced Microglial Death
por: Jekabsone, Aiste, et al.
Publicado: (2023)

Neuroprotective Effect of a Novel ATP-Synthase Inhibitor Bedaquiline in Cerebral Ischemia-Reperfusion Injury
por: Umbrasas, Danielius, et al.
Publicado: (2021)

Nitric Oxide Donor NOC-18-Induced Changes of Mitochondrial Phosphoproteome in Rat Cardiac Ischemia Model
por: Umbrasas, Danielius, et al.
Publicado: (2019)

Data on effects of rotenone on calcium retention capacity, respiration and activities of respiratory chain complexes I and II in isolated rat brain mitochondria
por: Rekuviene, Evelina, et al.
Publicado: (2017)

Extracellular tau stimulates phagocytosis of living neurons by activated microglia via Toll-like 4 receptor–NLRP3 inflammasome–caspase-1 signalling axis
por: Pampuscenko, Katryna, et al.
Publicado: (2023)

Immunogenic properties of amyloid beta oligomers
por: Dalgediene, Indre, et al.
Publicado: (2013)

Virus Mimetic Poly (I:C)-Primed Airway Exosome-like Particles Enter Brain and Induce Inflammatory Cytokines and Mitochondrial Reactive Oxygen Species in Microglia
por: Kulakauskienė, Deimantė, et al.
Publicado: (2021)

Microcirculatory, mitochondrial, and histological changes following cerebral ischemia in swine
por: Suchadolskiene, Olga, et al.
Publicado: (2014)

Influence of Technological Factors on the Quality of Chitosan Microcapsules with Boswellia serata L. Essential Oil
por: Pudziuvelyte, Lauryna, et al.
Publicado: (2022)

Influence of NADPH oxidase on inflammatory response in primary intestinal epithelial cells in patients with ulcerative colitis
por: Ramonaite, Rima, et al.
Publicado: (2013)

Effects of Metformin on Spontaneous Ca(2+) Signals in Cultured Microglia Cells under Normoxic and Hypoxic Conditions
por: Jankeviciute, Silvija, et al.
Publicado: (2021)

Fibrillar beta-amyloid peptide Aβ(1–40 )activates microglial proliferation via stimulating TNF-α release and H(2)O(2 )derived from NADPH oxidase: a cell culture study
por: Jekabsone, Aiste, et al.
Publicado: (2006)

Ursolic and Oleanolic Acids: Plant Metabolites with Neuroprotective Potential
por: Gudoityte, Evelina, et al.
Publicado: (2021)

Granzyme B Induces Bid-Mediated Cytochrome C Release and Mitochondrial Permeability Transition
por: Alimonti, Judie B., et al.
Publicado: (2001)

Neither a Nitric Oxide Donor Nor Potassium Channel Blockage Inhibit RBC Mechanical Damage Induced by a Roller Pump
por: Ulker, Pinar, et al.
Publicado: (2008)

Proteomic analysis links alterations of bioenergetics, mitochondria-ER interactions and proteostasis in hippocampal astrocytes from 3xTg-AD mice
por: Dematteis, Giulia, et al.
Publicado: (2020)

Blockage of MLKL prevents myelin damage in experimental diabetic neuropathy
por: Guo, Jia, et al.
Publicado: (2022)

Evaluation of the Effectiveness of Post-Stroke Metformin Treatment Using Permanent Middle Cerebral Artery Occlusion in Rats
por: Zemgulyte, Gintare, et al.
Publicado: (2021)

Extramitochondrial Ca(2+) in the Nanomolar Range Regulates Glutamate-Dependent Oxidative Phosphorylation on Demand
por: Gellerich, Frank Norbert, et al.
Publicado: (2009)

Substrate inhibition by the blockage of product release and its control by tunnel engineering
por: Kokkonen, Piia, et al.
Publicado: (2021)

Modulation of Human Cardiac TRPM7 Current by Extracellular Acidic pH Depends upon Extracellular Concentrations of Divalent Cations
por: Mačianskienė, Regina, et al.
Publicado: (2017)

Comparison of the Effect of Native 1,4-Naphthoquinones Plumbagin, Menadione, and Lawsone on Viability, Redox Status, and Mitochondrial Functions of C6 Glioblastoma Cells
por: Majiene, Daiva, et al.
Publicado: (2019)

The Role of Mitochondria in Brain Cell Protection from Ischaemia by Differently Prepared Propolis Extracts
por: Balion, Zbigniev, et al.
Publicado: (2020)

Acute and Sub-Chronic Intraperitoneal Toxicity Studies of the Elsholtzia ciliata Herbal Extract in Balb/c Mice
por: Mačianskienė, Regina, et al.
Publicado: (2023)

Challenges in the diagnosis and management of isolated congenital complete atrioventricular block in premature newborns
por: Gegieckienė, Rūta, et al.
Publicado: (2019)

Blockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia/reperfusion injury in mice
por: Dong, Qian, et al.
Publicado: (2017)

Functional Blockage of S100A8/A9 Ameliorates Ischemia–Reperfusion Injury in the Lung
por: Nakata, Kentaro, et al.
Publicado: (2022)

Elsholtzia ciliata (Thunb.) Hyl. Extracts from Different Plant Parts: Phenolic Composition, Antioxidant, and Anti-Inflammatory Activities
por: Pudziuvelyte, Lauryna, et al.
Publicado: (2020)

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg(2+) Ions
por: Eskes, Robert, et al.
Publicado: (1998)

Semaphorin3A elevates vascular permeability and contributes to cerebral ischemia-induced brain damage
por: Hou, Sheng Tao, et al.
Publicado: (2015)

Freeze-Drying Technique for Microencapsulation of Elsholtzia ciliata Ethanolic Extract Using Different Coating Materials
por: Pudziuvelyte, Lauryna, et al.
Publicado: (2020)

Nitric oxide, leukocytes and microvascular permeability: causality or bystanders?
por: Hauser, Balázs, et al.
Publicado: (2008)

Blockage of cell-to-cell communication within pancreatic acini is associated with increased basal release of amylase
Publicado: (1986)

Blockage of Squamous Cancer Cell Collective Invasion by FAK Inhibition Is Released by CAFs and MMP-2
por: Sáenz-de-Santa-María, Inés, et al.
Publicado: (2020)

Ginsenoside Rd Attenuates Mitochondrial Permeability Transition and Cytochrome c Release in Isolated Spinal Cord Mitochondria: Involvement of Kinase-Mediated Pathways
por: Zhou, Jin-Song, et al.
Publicado: (2014)

Systemic Blockage of Nitric Oxide Synthase by L-NAME Increases Left Ventricular Systolic Pressure, Which Is Not Augmented Further by Intralipid(®)
por: Shin, Il-Woo, et al.
Publicado: (2014)

Inhibition of Bcl-2 Sensitizes Mitochondrial Permeability Transition Pore (MPTP) Opening in Ischemia-Damaged Mitochondria
por: Chen, Qun, et al.
Publicado: (2015)

Species-Specific Plant-Derived Nanoparticle Characteristics
por: Viršilė, Akvilė, et al.
Publicado: (2022)

Adipose Tissue-Derived Stem Cell Extracellular Vesicles Suppress Glioblastoma Proliferation, Invasiveness and Angiogenesis
por: Gečys, Dovydas, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3mladljcfpciigbng2bbbo9g0d