Attenuation of prostaglandin E(2 )elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole

BACKGROUND: Peripheral administration of lipopolysaccharide (LPS) induces inflammation and increases cerebral prostaglandin E(2 )(PGE(2)) concentration. PGE(2 )is eliminated from brain across the blood-brain barrier (BBB) in mice, and this process is inhibited by intracerebral or intravenous pre-adm...

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Detalles Bibliográficos
Autores principales: Akanuma, Shin-ichi, Uchida, Yasuo, Ohtsuki, Sumio, Tachikawa, Masanori, Terasaki, Tetsuya, Hosoya, Ken-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224590/
https://www.ncbi.nlm.nih.gov/pubmed/22014165
http://dx.doi.org/10.1186/2045-8118-8-24

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