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Hip fracture history and risk of nonmelanoma skin cancer: a Danish population-based study
BACKGROUND: Vitamin D deficiency is associated with osteoporotic fractures, such as hip fracture. Sun exposure, the natural source of vitamin D, is the main risk factor for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). In this study, we examined the association between a history of h...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224634/ https://www.ncbi.nlm.nih.gov/pubmed/22135503 http://dx.doi.org/10.2147/CLEP.S25650 |
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author | Lamberg, Anna Lei Olesen, Anne Braae Jensen, Annette Østergaard |
author_facet | Lamberg, Anna Lei Olesen, Anne Braae Jensen, Annette Østergaard |
author_sort | Lamberg, Anna Lei |
collection | PubMed |
description | BACKGROUND: Vitamin D deficiency is associated with osteoporotic fractures, such as hip fracture. Sun exposure, the natural source of vitamin D, is the main risk factor for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). In this study, we examined the association between a history of hip fracture and risk of BCC and SCC. METHODS: We conducted a population-based case-controlled study using data on BCC and SCC cases registered in the Danish Cancer Registry from 1990–2005. For each case, we selected five population controls matched by age and gender. We used conditional logistic regression to compute odds ratios (OR) and 95% confidence intervals (CI), while adjusting for chronic diseases and socioeconomic status. RESULTS: A history of hip fracture was associated with a decreased risk of BCC (OR 0.90, 95% CI 0.85–0.94), which was most pronounced in cases of tumors on the trunk, extremities, or at multiple sites. We found no association for SCC (OR 1.07, 95% CI 0.98–1.17). CONCLUSION: Our study showed an inverse association between history of hip fracture and risk of BCC, but not of SCC. Sun exposure, resulting in vitamin D synthesis, may explain the link between the two diseases. |
format | Online Article Text |
id | pubmed-3224634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-32246342011-12-01 Hip fracture history and risk of nonmelanoma skin cancer: a Danish population-based study Lamberg, Anna Lei Olesen, Anne Braae Jensen, Annette Østergaard Clin Epidemiol Original Research BACKGROUND: Vitamin D deficiency is associated with osteoporotic fractures, such as hip fracture. Sun exposure, the natural source of vitamin D, is the main risk factor for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). In this study, we examined the association between a history of hip fracture and risk of BCC and SCC. METHODS: We conducted a population-based case-controlled study using data on BCC and SCC cases registered in the Danish Cancer Registry from 1990–2005. For each case, we selected five population controls matched by age and gender. We used conditional logistic regression to compute odds ratios (OR) and 95% confidence intervals (CI), while adjusting for chronic diseases and socioeconomic status. RESULTS: A history of hip fracture was associated with a decreased risk of BCC (OR 0.90, 95% CI 0.85–0.94), which was most pronounced in cases of tumors on the trunk, extremities, or at multiple sites. We found no association for SCC (OR 1.07, 95% CI 0.98–1.17). CONCLUSION: Our study showed an inverse association between history of hip fracture and risk of BCC, but not of SCC. Sun exposure, resulting in vitamin D synthesis, may explain the link between the two diseases. Dove Medical Press 2011-11-17 /pmc/articles/PMC3224634/ /pubmed/22135503 http://dx.doi.org/10.2147/CLEP.S25650 Text en © 2011 Lamberg et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Lamberg, Anna Lei Olesen, Anne Braae Jensen, Annette Østergaard Hip fracture history and risk of nonmelanoma skin cancer: a Danish population-based study |
title | Hip fracture history and risk of nonmelanoma skin cancer: a Danish population-based study |
title_full | Hip fracture history and risk of nonmelanoma skin cancer: a Danish population-based study |
title_fullStr | Hip fracture history and risk of nonmelanoma skin cancer: a Danish population-based study |
title_full_unstemmed | Hip fracture history and risk of nonmelanoma skin cancer: a Danish population-based study |
title_short | Hip fracture history and risk of nonmelanoma skin cancer: a Danish population-based study |
title_sort | hip fracture history and risk of nonmelanoma skin cancer: a danish population-based study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224634/ https://www.ncbi.nlm.nih.gov/pubmed/22135503 http://dx.doi.org/10.2147/CLEP.S25650 |
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