Anti-tumor effects of a human VEGFR-2-based DNA vaccine in mouse models

BACKGROUND: Vascular endothelial growth factor (VEGF) and its receptor, VEGFR-2 (Flk-1/KDR), play a key role in tumor angiogenesis. Blocking the VEGF-VEGFR-2 pathway may inhibit tumor growth. Here, we used human VEGFR-2 as a model antigen to explore the feasibility of immunotherapy with a plasmid DN...

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Detalles Bibliográficos
Autores principales: Xie, Ke, Bai, Rui-Zhen, Wu, Yang, Liu, Quan, Liu, Kang, Wei, Yu-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224891/
https://www.ncbi.nlm.nih.gov/pubmed/19545394
http://dx.doi.org/10.1186/1479-0556-7-10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224891/
https://www.ncbi.nlm.nih.gov/pubmed/19545394
http://dx.doi.org/10.1186/1479-0556-7-10

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