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Anti-tumor effects of a human VEGFR-2-based DNA vaccine in mouse models

BACKGROUND: Vascular endothelial growth factor (VEGF) and its receptor, VEGFR-2 (Flk-1/KDR), play a key role in tumor angiogenesis. Blocking the VEGF-VEGFR-2 pathway may inhibit tumor growth. Here, we used human VEGFR-2 as a model antigen to explore the feasibility of immunotherapy with a plasmid DN...

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Detalles Bibliográficos
Autores principales:	Xie, Ke, Bai, Rui-Zhen, Wu, Yang, Liu, Quan, Liu, Kang, Wei, Yu-Quan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224891/ https://www.ncbi.nlm.nih.gov/pubmed/19545394 http://dx.doi.org/10.1186/1479-0556-7-10

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