Altering the Electrostatic Potential in the Major Groove: Thermodynamic and Structural Characterization of 7-Deaza-2′-deoxyadenosine:dT Base Pairing in DNA

[Image: see text] As part of an ongoing effort to explore the effect of major groove electrostatics on the thermodynamic stability and structure of DNA, a 7-deaza-2′-deoxyadenosine:dT (7-deaza-dA:dT) base pair in the Dickerson–Drew dodecamer (DDD) was studied. The removal of the electronegative N7 a...

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Detalles Bibliográficos
Autores principales: Kowal, Ewa A., Ganguly, Manjori, Pallan, Pradeep S., Marky, Luis A., Gold, Barry, Egli, Martin, Stone, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225014/
https://www.ncbi.nlm.nih.gov/pubmed/22059929
http://dx.doi.org/10.1021/jp207104w

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